1. Molecular Biology Fourth Edition Chapter 1 A Brief History Robert F. Weaver Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

2. 1-2 A Brief History What is molecular biology? –The attempt to understand biological phenomena in molecular terms –The study of gene structure and function at the molecular level Molecular biology is a melding of aspects of genetics and biochemistry

3. Opener Mendel’s Laws of Inheritance (1865) 1822-1884 Gene Blending  particle allele

4. Chromosome theory Recombination in Drosophila 1910 The Chromosome Theory of Inheritance Thomas Hunt Morgan used the fruit fly, Drosophila melanogaster

5. Fig. 1.5 Physical Evidence for Recombination Microscopic examination of maize chromosome (1931); crossing-over, transposon (coloration of kernel) 1902- 1992; 1983

6. Fig. 1.8 Beadle & Tatum Neurospora 1941 One-gene/one-enzyme hypothesis One-gene/one- ooo hypothesis

7. Fig. 1.9

8. Fig. 1.10

9. Fig. 1.13 Genetic code, 1966

10. Tab. 1.1

11. Tab. 1.1(continued) 2009 ? ? 2020 ? ? 2030

12. How to study ? Essential terms –Gene, allele, inheritance, maize, Neurospora, genotype, phynotype…. Lecture images, lecture notes Web site ; http://www.molbiology-dongguk.ac.kr/