1. IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Rα in T cells by Catarina M. Henriques, José Rino, Robert J. Nibbs, Gerry J. Graham, and João T. Barata Blood Volume 115(16):3269-3277 April 22, 2010 ©2010 by American Society of Hematology

2. IL-7 induces rapid IL-7Rα surface down-regulation resulting from receptor internalization. Catarina M. Henriques et al. Blood 2010;115:3269-3277 ©2010 by American Society of Hematology

3. IL-7Rα internalization via clathrin-coated pits and trafficking into early endosomes is required for efficient IL-7–mediated signaling. Catarina M. Henriques et al. Blood 2010;115:3269-3277 ©2010 by American Society of Hematology

4. A pool of internalized IL-7Rα recycles to the cell surface. Catarina M. Henriques et al. Blood 2010;115:3269-3277 ©2010 by American Society of Hematology

5. IL-7 stimulation accelerates IL-7Rα degradation, in a lysosome and proteasome-dependent manner. Catarina M. Henriques et al. Blood 2010;115:3269-3277 ©2010 by American Society of Hematology

6. IL-7–induced IL-7Rα degradation, but not internalization, is JAK3 dependent. Catarina M. Henriques et al. Blood 2010;115:3269-3277 ©2010 by American Society of Hematology

7. Proposed model for IL-7Rα trafficking. Catarina M. Henriques et al. Blood 2010;115:3269-3277 ©2010 by American Society of Hematology