1. Date of download: 9/19/2016 From: Personalizing Age of Cancer Screening Cessation Based on Comorbid Conditions: Model Estimates of Harms and Benefits Ann Intern Med. 2014;161(2):104-112. doi:10.7326/M13-2867 Observed and simulated cancer incidence rates, by calendar year of diagnosis (breast and prostate cancer) or age at diagnosis (colorectal cancer). Panels show age-standardized breast cancer incidence rates per 100 000 women aged 30 to 79 y for MISCAN-Fadia and G-E models, age-standardized prostate cancer incidence rates per 100 000 men aged 50 to 84 y for MISCAN-Prostate and FHCRC models, and colorectal incidence rates per 100 000 persons for years 1975 to 1979 for MISCAN-Colon, CRC-SPIN, and SimCRC models. CRC-SPIN = Colorectal Cancer Simulated Population Model for Incidence and Natural History; Fadia = fatal diameter; FHCRC = Fred Hutchinson Cancer Research Center; G-E = Georgetown–Einstein; MISCAN = Microsimulation Screening Analysis; SEER = Surveillance, Epidemiology, and End Results; SimCRC = Simulating Colorectal Cancer. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 9/19/2016 From: Personalizing Age of Cancer Screening Cessation Based on Comorbid Conditions: Model Estimates of Harms and Benefits Ann Intern Med. 2014;161(2):104-112. doi:10.7326/M13-2867 NNS/LYG for screening at the plotted age, by comorbid condition level. The horizontal dashed line represents the NNS/LYG for screening the average-health population until age 76 y (75 y for colorectal cancer). The vertical dashed lines indicate the age for each comorbid condition group at which screening provided harms and benefits similar to screening at age 74 y in the average-health population (oldest age for which the NNS/LYG falls under the vertical dotted line). Panels show NNS/LYG projected by different models. CRC-SPIN = Colorectal Cancer Simulated Population Model for Incidence and Natural History; Fadia = fatal diameter; FHCRC = Fred Hutchinson Cancer Research Center; G-E = Georgetown–Einstein; MISCAN = Microsimulation Screening Analysis; NNS/LYG = number needed to screen per life-year gained; SimCRC = Simulating Colorectal Cancer. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 9/19/2016 From: Personalizing Age of Cancer Screening Cessation Based on Comorbid Conditions: Model Estimates of Harms and Benefits Ann Intern Med. 2014;161(2):104-112. doi:10.7326/M13-2867 Age at which harms and benefits of screening were similar to those for persons with average health having screening at age 74 y. The green bars represent the median age, and the uncertainty bars represent the range across all models and cancer sites. For no comorbid conditions, the lowest cessation age across models and cancer sites coincides with the median age (see Tables 2 to 8 of the Supplement and Figure 1). Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians