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Zoltan G. Turi, M.D. Professor of Medicine University of Medicine and Dentistry of New Jersey A Bad Vascular Access and Closure Outcome
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Disclosure Information Zoltan G. Turi MD, FSCAI Grant/Research Support: Abbott, Arstasis, Cordis, Marine Polymer Technologies, St. Jude Medical
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History 48 year old hypertensive diabetic ♀ Anterior ischemia Routine PCI Heparin – ACT 240 Eptifibatide Aspirin and clopidogrel loading Bifurcation stenting – sheath ↑ 7 F DES placed LAD with good result Agitated during much of case – difficult to sedate BP ↑
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Systolic BP during procedure mm Hg 10:48 am12:08 pm
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Post procedure femoral angio
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Angio-Seal deployed by fellow ~ 12:10 Attending with little VCD experience Patient sent to step down No special warnings or other communication with staff Initial BP in step down = 120 mm Hg Regular staff went on break ~ 12:30 pm
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BP now 100 Patient became agitated Fellow sees patient and calls attending Attending – in office - ordered antihistamines and steroids Repeat BP ~ 100 mm Hg Fellow still worried CT scan ordered Staff worried Ask another attending to take a look Other attending worried
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Patient rushed to lab
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mm Hg intra- procedure Step- down 10:48 am12:08 am
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Post mortem Large retroperitoneal bleed Closure device in place – some space between plug and arterial wall
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Insertion IEA
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A D C F E B CCI 2011 Freilich
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What went wrong here 1. High stick 2. Failure to recognize high stick prior to sheath placement/upsizing sheath 3. Failure to recognize high stick prior to anticoagulation 4. Use of closure device after PCI with high stick 5. Failure to recognize “bladder sign”
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6. Sending patient to recovery 7. Failure to communicate with nursing staff implications of high stick/bladder compression 8. Shift change 9. Failure to recognize importance of lower BP and agitation 10. Failure to intervene early
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11. Failure to transfuse 12. Wrong groin used for access 13. Too little, too late
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1 – Preflight 2 – Consider alternatives 3 – Micropuncture 4 – Ultrasound and/or iterative fluoroscopy 5 – Femoral angiogram every case 6 – If stick approaches within 5 mm of IEA – no anticoagulation or antiplatelet Rx – can do diagnostic 7 – Bivalirudin or weight adjusted heparin – begin with < 40 units/kg 8 –Closure is not for the inexperienced or unsupervised 9 - No VCD for puncture within 5 mm of IEA 10 –VCD appropriate to situation or no VCD Preflight
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Checklist – 1 Preflight History of prior access Examine potential access sites Palpate, auscultate, distal pulses, ABIs - record Review prior femoral angiograms
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1 – Preflight 2 – Consider alternatives 3 – Micropuncture 4 – Ultrasound and/or iterative fluoroscopy 5 – Femoral angiogram every case 6 – If stick approaches within 5 mm of IEA – no anticoagulation or antiplatelet Rx – can do diagnostic 7 – Bivalirudin or weight adjusted heparin – begin with < 40 units/kg 8 –Closure is not for the inexperienced or unsupervised 9 - No VCD for puncture within 5 mm of IEA 10 –VCD appropriate to situation or no VCD Consider alternatives
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2 - Consider Radial
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1 – Preflight 2 – Consider alternatives 3 – Micropuncture 4 – Ultrasound and/or iterative fluoroscopy 5 – Femoral angiogram every case 6 – If stick approaches within 5 mm of IEA – no anticoagulation or antiplatelet Rx – can do diagnostic 7 – Bivalirudin or weight adjusted heparin – begin with < 40 units/kg 8 –Closure is not for the inexperienced or unsupervised 9 - No VCD for puncture within 5 mm of IEA 10 –VCD appropriate to situation or no VCD Micropuncture
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3 - Micropuncture
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Some simple math ~ 7 th grade Flow = Pressure/Resistance Resistance = viscosity * length radius 4 If Pressure, viscosity and length fixed Then Flow ~ radius 4
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5.9 fold in blood loss In size = 56% Std needle (18g) = 1.27 mm Micropuncture (21g) =.813 mm
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1 – Preflight 2 – Consider alternatives 3 – Micropuncture 4 – Ultrasound and/or iterative fluoroscopy 5 – Femoral angiogram every case 6 – If stick approaches within 5 mm of IEA – no anticoagulation or antiplatelet Rx – can do diagnostic 7 – Bivalirudin or weight adjusted heparin – begin with < 40 units/kg 8 –Closure is not for the inexperienced or unsupervised 9 - No VCD for puncture within 5 mm of IEA 10 –VCD appropriate to situation or no VCD Ultrasound and/or iterative fluoroscopy
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1 – Preflight 2 – Consider alternatives 3 – Micropuncture 4 – Ultrasound and/or iterative fluoroscopy Optimize access Ultrasound and/or iterative fluoroscopy
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BIF IEA Cumulative Target Zone FH Centerline
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Smallest sheath possible Trimarchi JACC CI 2010
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1 – Preflight 2 – Consider alternatives 3 – Micropuncture 4 – Ultrasound and/or iterative fluoroscopy 5 – Femoral angiogram every case 6 – If stick approaches within 5 mm of IEA – no anticoagulation or antiplatelet Rx – can do diagnostic 7 – Bivalirudin or weight adjusted heparin – begin with < 40 units/kg 8 –Closure is not for the inexperienced or unsupervised 9 - No VCD for puncture within 5 mm of IEA 10 – No unanchored devices for anticoagulated patients No VCD or VCD appropriate to situation Femoral angiogram every case
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Femoral Angio Everyone Age Gender Diabetes ↓ Body surface area Sheath size Vessel size* Anticoagulation Puncture location* Prior instrumentation Vascular disease at puncture site* ? IIb/IIIa * = requires femoral angio Know anatomy for next time
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1 – Preflight 2 – Consider alternatives 3 – Micropuncture 4 – Ultrasound and/or iterative fluoroscopy 5 – Femoral angiogram every case 6 – If stick approaches within 5 mm of IEA – no anticoagulation or antiplatelet Rx – can do diagnostic 7 – Bivalirudin or weight adjusted heparin – begin with < 40 units/kg 8 –Closure is not for the inexperienced or unsupervised 9 - No VCD for puncture within 5 mm of IEA 10 – No unanchored devices for anticoagulated patients No VCD or VCD appropriate to situation 6 – If stick approaches within 5 mm of IEA – no anticoagulation or antiplatelet Rx – can do diagnostic
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1 – Preflight 2 – Consider alternatives 3 – Micropuncture 4 – Ultrasound and/or iterative fluoroscopy 5 – Femoral angiogram every case 6 – If stick approaches within 5 mm of IEA – no anticoagulation or antiplatelet Rx – can do diagnostic 7 – Bivalirudin or weight adjusted heparin – begin with < 40 units/kg 8 –Closure is not for the inexperienced or unsupervised 9 - No VCD for puncture within 5 mm of IEA 10 – No unanchored devices for anticoagulated patients No VCD or VCD appropriate to situation 7 – Bivalirudin or weight adjusted heparin – begin with < 40 units/kg/needle mgmt/groin mgmt
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Bleeding Complications Blankenship. CCI 2002. Dauerman JACC 2007
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Strategies Minimizing Bleeding Weight-adjusted heparin Lower heparin dose No postprocedure heparin No venous sheath Smaller guiding catheter Fixed dose heparin should largely disappear
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Consider bivalirudin Trimarchi JACC CI 2010
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Needle management Avoid multiple sticks, posterior wall sticks Stop and compress if failed puncture Anterior wall only, good blood flow, no resistance to wire
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1 – Preflight 2 – Consider alternatives 3 – Micropuncture 4 – Ultrasound and/or iterative fluoroscopy 5 – Femoral angiogram every case 6 – If stick approaches within 5 mm of IEA – no anticoagulation or antiplatelet Rx – can do diagnostic 7 – Bivalirudin or weight adjusted heparin – begin with < 40 units/kg 8 –Closure is not for the inexperienced or unsupervised 9 - No VCD for puncture within 5 mm of IEA 10 – No unanchored devices for anticoagulated patients, VCD appropriate to situation or no VCD 8 –Closure is not for the inexperienced or unsupervised 9 - No VCD for puncture within 5 mm of IEA 10 –VCD appropriate to situation or no VCD
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Suspicion of RPH Stable CT Scan
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Suspicion of RPH ShockStable Cath lab* Contralateral Access Tamponade Leak CT Scan Transfuse ! Reverse Anticoagulation !
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