Presentation is loading. Please wait.

Presentation is loading. Please wait.

Group Sequential Tests for Delayed Responses Christopher Jennison Department of Mathematical Sciences University of Bath Lisa Hampson Department of Mathematics.

Published byLouise Burns Modified over 7 years ago

Similar presentations

Presentation on theme: "Group Sequential Tests for Delayed Responses Christopher Jennison Department of Mathematical Sciences University of Bath Lisa Hampson Department of Mathematics."— Presentation transcript:

1 Group Sequential Tests for Delayed Responses Christopher Jennison Department of Mathematical Sciences University of Bath Lisa Hampson Department of Mathematics and Statistics University of Lancaster BfArM/DIA Statistics Workshop Bonn October 2012

2 The views and opinions expressed in the following PowerPoint slides are those of the individual presenter and should not be attributed to Drug Information Association, Inc. (“DIA”), its directors, officers, employees, volunteers, members, chapters, councils, Special Interest Area Communities or affiliates, or any organization with which the presenter is employed or affiliated. These PowerPoint slides are the intellectual property of the individual presenter and are protected under the copyright laws of the United States of America and other countries. Used by permission. All rights reserved. Drug Information Association, DIA and DIA logo are registered trademarks or trademarks of Drug Information Association Inc. All other trademarks are the property of their respective owners. Disclaimer 2www.diahome.orgDrug Information Association

3 Outline of talk Drug Information Associationwww.diahome.org3

4 1. Group sequential monitoring of clinical trials Drug Information Associationwww.diahome.org4

5 A group sequential test (GST) Drug Information Associationwww.diahome.org5

6 2. The problem of delayed responses Drug Information Associationwww.diahome.org6

7 The problem of delayed responses Drug Information Associationwww.diahome.org7

8 Short term information on “pipeline” subjects Drug Information Associationwww.diahome.org8

9 3. Defining a group sequential test with delayed responses Drug Information Associationwww.diahome.org9

10 Boundaries for a Delayed Response GST Drug Information Associationwww.diahome.org10

11 Calculations for a Delayed Response GST Drug Information Associationwww.diahome.org11

12 The value of information from pipeline subjects Drug Information Associationwww.diahome.org12

13 The value of information from pipeline subjects Drug Information Associationwww.diahome.org13

14 4. Optimising a Delayed Response GST Drug Information Associationwww.diahome.org14

15 Computing optimal Delayed Response GSTs Drug Information Associationwww.diahome.org15

16 An optimal design for the cholesterol example Drug Information Associationwww.diahome.org16

17 An optimal design for the cholesterol example Drug Information Associationwww.diahome.org17

18 An optimal design for the cholesterol example Drug Information Associationwww.diahome.org18

19 An optimal design for the cholesterol example Drug Information Associationwww.diahome.org 19

20 Efficiency loss when there is a delay in response Drug Information Associationwww.diahome.org20

21 5. Using a short term endpoint to recover efficiency Drug Information Associationwww.diahome.org21

22 Using a short term endpoint to recover efficiency Drug Information Associationwww.diahome.org22

23 Using a short term endpoint to recover efficiency Drug Information Associationwww.diahome.org23

24 Using a short term endpoint to recover efficiency Drug Information Associationwww.diahome.org24

25 6. Error spending Delayed Response GSTs Drug Information Associationwww.diahome.org25

26 The ρ-family of error spending functions Drug Information Associationwww.diahome.org26

27 7. Further topics Drug Information Associationwww.diahome.org27

28 Further topics Drug Information Associationwww.diahome.org28

29 Further topics Drug Information Associationwww.diahome.org29

30 Further topics Drug Information Associationwww.diahome.org30

Download ppt "Group Sequential Tests for Delayed Responses Christopher Jennison Department of Mathematical Sciences University of Bath Lisa Hampson Department of Mathematics."

Similar presentations

Patients’ Perspective on HTA and Off-label use David Head MBA Chief Executive RP Fighting Blindness 25th Annual EuroMeeting 4-6 March 2013 RAI, Amsterdam.

Patients’ Perspective on HTA and Off-label use David Head MBA Chief Executive RP Fighting Blindness 25th Annual EuroMeeting 4-6 March 2013 RAI, Amsterdam.
Data Monitoring Models and Adaptive Designs: Some Regulatory Experiences Sue-Jane Wang, Ph.D. Associate Director for Adaptive Design and Pharmacogenomics,

Data Monitoring Models and Adaptive Designs: Some Regulatory Experiences Sue-Jane Wang, Ph.D. Associate Director for Adaptive Design and Pharmacogenomics,
The Changing Face of Endpoint Security K Varadarajan Regional Manager, Enterprise Sales, Symantec Security Conference 2010_Bangalore.

The Changing Face of Endpoint Security K Varadarajan Regional Manager, Enterprise Sales, Symantec Security Conference 2010_Bangalore.
© 2010 Pearson Education, Inc. All rights reserved.

© 2010 Pearson Education, Inc. All rights reserved.
Orphan Drugs: Where have we been; Where are we now; Where are we going Marlene E. Haffner, MD, MPH Haffner Associates, LLC 11 October,

Orphan Drugs: Where have we been; Where are we now; Where are we going Marlene E. Haffner, MD, MPH Haffner Associates, LLC 11 October,
Career Symposium Presentation for Middle School A Product of Creativity in Bloom Sal Anastasi 2010.

Career Symposium Presentation for Middle School A Product of Creativity in Bloom Sal Anastasi 2010.
Clinical Trials in the Age of Personalized Cancer Medicine: The Evolution of a More Efficient, Patient Focused Clinical Research System Session Chair:

Clinical Trials in the Age of Personalized Cancer Medicine: The Evolution of a More Efficient, Patient Focused Clinical Research System Session Chair:
The Correct e- Mixtures (A fully validated EHR, the way forward) Brendan Delaney Guy’s and St Thomas’ Charity Chair in Primary Care Research.

The Correct e- Mixtures (A fully validated EHR, the way forward) Brendan Delaney Guy’s and St Thomas’ Charity Chair in Primary Care Research.
FDA’s Biosimilars Guidance -- Legal and Regulatory Considerations James S. Cohen, Esq. McDermott Will & Emery DIA Webinar April 10, 2012.

FDA’s Biosimilars Guidance -- Legal and Regulatory Considerations James S. Cohen, Esq. McDermott Will & Emery DIA Webinar April 10, 2012.
Disclaimer The views and opinions expressed in the following PowerPoint slides are those of the individual presenter and should not be attributed to Drug.

Disclaimer The views and opinions expressed in the following PowerPoint slides are those of the individual presenter and should not be attributed to Drug.
Introduction to Drug Rediscovery John Lisman Attorney-at-law Lisman Legal Life sciences Insert your logo in this area then delete this text box.

Introduction to Drug Rediscovery John Lisman Attorney-at-law Lisman Legal Life sciences Insert your logo in this area then delete this text box.
How to audit the role of the vendor in the conduct of outsourced studies Kristel Van de Voorde Director Global Quality Regulatory Compliance Bristol-Myers.

How to audit the role of the vendor in the conduct of outsourced studies Kristel Van de Voorde Director Global Quality Regulatory Compliance Bristol-Myers.
12341234 Presenter Name Title Organization Twitter Handle Insert your logo here, then delete text.

Presenter Name Title Organization Twitter Handle Insert your logo here, then delete text.
Quick Thoughts on PGP Use Cases for KMIP 1 Michael Allen Sr. Technical Director.

Quick Thoughts on PGP Use Cases for KMIP 1 Michael Allen Sr. Technical Director.
1 “Something to put it in perspective…” Slide Show Name “Something to put it in perspective…” Presented by: Andy Lindsay Parallax, Inc.

1 “Something to put it in perspective…” Slide Show Name “Something to put it in perspective…” Presented by: Andy Lindsay Parallax, Inc.
Click to add Presentation Title Arial 32, 5 line max title space line 3, title space line 4, title space line 5 Presenter Title Organization Insert your.

Click to add Presentation Title Arial 32, 5 line max title space line 3, title space line 4, title space line 5 Presenter Title Organization Insert your.
© 2008 Verizon. All Rights Reserved. PTE13015 06/08 GLOBAL CAPABILITY. PERSONAL ACCOUNTABILITY. Verizon Instant Net Conference powered by Cisco-WebEx T26.

© 2008 Verizon. All Rights Reserved. PTE /08 GLOBAL CAPABILITY. PERSONAL ACCOUNTABILITY. Verizon Instant Net Conference powered by Cisco-WebEx T26.
1 Optimal Strategies for Preparing Integrated and Clinical Summaries for a New Drug Application: Making it Work Under Any Circumstance Lisa A. Pierchala,

1 Optimal Strategies for Preparing Integrated and Clinical Summaries for a New Drug Application: Making it Work Under Any Circumstance Lisa A. Pierchala,
© 2014 Gartner, Inc. and/or its affiliates. All rights reserved. Gartner is a registered trademark of Gartner, Inc. or its affiliates. This publication.

© 2014 Gartner, Inc. and/or its affiliates. All rights reserved. Gartner is a registered trademark of Gartner, Inc. or its affiliates. This publication.
Bayesian approach to equivalence study of medical device 1 1.

Bayesian approach to equivalence study of medical device 1 1.

Similar presentations

Ads by Google