2. CERN-MEDICIS: Production d’isotopes selon l’approche « ISOLDE » pour la recherche médicale Thierry Stora EN-STI EN-GMS 5 th March 2013

3. Overview 2 When a CERN proton beam intercepts a target: Which can well lead to this result if not careful… But will be used to produce Innovative isotopes for this:

4. 3 The ISOLDE facility

5. Isolde at CERN

6. Experiment hall Class A work sector Up to 50% of total CERN proton are delivered to ISOLDE The On-Line Isotope Mass Separator ISOLDE is a facility dedicated to the production of a large variety of radioactive ion beams for a great number of different experiments, e.g. in the field of nuclear and atomic physics, solid-state physics, life sciences and material science 5 The ISOLDE facility

7. Ion Beam Production spallation fragmentation fission 1.4 GeV protons Target Unit Front End (target station) 6

8. Mass spectrometers 7 GPS HRS

9. 1000+ isotopes (for 70+ elements) “online” Exotic isotopes down to t 1/2 ~ 10 ms) Intensities up to 10 11 ions/s 30+ types of targets Transfer lines 10+ ion sources

10. Nuclear structures T. Stora 14th November 2012 Studies of nuclear pear-shapes using accelerated radioactive beams Accepted to Nature

11. The « ISOL » filter 10 In-target production rate Beam production rate (release + ionization) Mass separation A=83 A=152

12. Protons in the dump 30-50% of 1.4GeV CERN protons reach the dump there Characteristics of MEDICIS -1.4GeV, 2  A, proton beam -About 90% of proton beam intensity pass through the Isolde targets

13. 12 Full MEDICIS principle Test samples collected at ISOLDE and shipped to Lausanne Hospital in August 2012

14. 13 Example : 61 Cu Isotope inventory Y 2 O 3 target (2g/cm 3 ) 2  A proton beam 4 hours A=61 Cu Activity [Bq] (15min decay) Activity [Bq] (3hours decay)

15. Layout 14 Transport system Buffer area Spectroscopy & shipping Laboratory Medicis Target & Mass separator

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17. Bombesin peptide analog that specifically binds to prostate cancer tissues Batch collected at ISOLDE and exported to CHUV Tests on mice already showed better biodistribution (less toxicity to healthy tissues) than same peptide + 68Ga  Candidate for next therapeutic trials with 149Tb/161Tb _ Hello, My name is… Bombina bombina Bombesin 152Tb From ISOLDE Bombesin Prostate Cancer cells Test experiment

18. 17 Principle Injection imaging agent, then treatment agent (drug) Imaging, drug localisation Cancer diagnosed Cancer tissue specifically targeted with minimal impact on healthy tissues

19. Treatment of Lupus disease: Dr. Danlos, insitut Curie, 1st proposed in 1901 By Pierre Curie Application of a source of Radium (223, 224?) to skin lesions Curie therapy

20. Dr. Forni (Clin. Carouge) Prof. Morel, Prof. Buehler Dr. Y. Seimbille, Prof. Ratib (HCUGE) Prof. D. Hanahan (ISREC, EPFL, Lausanne) Prof. J. Prior (CHUV, Lausanne) Prof M. Huyse, prof. P. van Duppen (Univ. Leuven) Prof. S. Lahiri (SINP, Kolkata) External partners

21. Prof D. Hanahan, Swiss Inst. For Exper. Cancer Research External partners

22. MEDICIS Timeline Design of layout and building ongoing Civil engineering foreseen to start in 2013 (LS1) MEDICIS Laboratory commissioning - mid 2015 Aim at starting production and shipping of first batches - end 2015 Thank you ! 21

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