1. Date of download: 7/8/2016 From: Longer- Versus Shorter-Duration Dual-Antiplatelet Therapy After Drug-Eluting Stent Placement: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(2):118-126. doi:10.7326/M15-0083 Summary of evidence search and selection. * Records were identified using Ovid MEDLINE and EMBASE (1996 to 27 March 2015). † Data from a later manuscript were used. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 7/8/2016 From: Longer- Versus Shorter-Duration Dual-Antiplatelet Therapy After Drug-Eluting Stent Placement: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(2):118-126. doi:10.7326/M15-0083 Assessment of risk of bias. See the legend for Figure 1 for abbreviation expansions. A green circle with a plus sign means no risk of bias; a red circle with a minus sign means potential risk of bias. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 7/8/2016 From: Longer- Versus Shorter-Duration Dual-Antiplatelet Therapy After Drug-Eluting Stent Placement: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(2):118-126. doi:10.7326/M15-0083 Pooled risk for death with longer- versus shorter-duration DAPT after placement of a drug-eluting stent. ARCTIC-Interruption = Assessment by a double Randomization of a Conventional antiplatelet strategy versus a monitoring-guided strategy for drug-eluting stent implantation and, of Treatment Interruption versus Continuation 1 year after stenting Interruption Study; DAPT = dual-antiplatelet therapy; DES LATE = Optimal Duration of Clopidogrel Therapy With Drug Eluting Stents to Reduce Late Coronary Arterial Thrombotic Event Study; EXCELLENT = Efficacy of Xience/Promus Versus Cypher to Reduce Late Loss After Stenting; ISAR-SAFE = Intracoronary Stenting and Antithrombotic Regimen: Safety And EFficacy of 6 Months Dual Antiplatelet Therapy After Drug-Eluting Stenting; ITALIC = Is There A Life for DES after Discontinuation of Clopidogrel; OPTIMIZE = Optimized Duration of Clopidogrel Therapy Following Treatment With the Zotarolimus-Eluting Stent in Real-World Clinical Practice Study; PRODIGY = Prolonging Dual Antiplatelet Treatment After Grading Stent- Induced Intimal Hyperplasia Study; SECURITY = Second Generation Drug-Eluting Stent Implantation Followed by Six- Versus Twelve-Month Dual Antiplatelet Therapy. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 7/8/2016 From: Longer- Versus Shorter-Duration Dual-Antiplatelet Therapy After Drug-Eluting Stent Placement: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(2):118-126. doi:10.7326/M15-0083 Pooled risk for cardiovascular death with longer- versus shorter-duration DAPT after placement of a drug-eluting stent. See the legend for Figure 1 for abbreviation expansions. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5. Date of download: 7/8/2016 From: Longer- Versus Shorter-Duration Dual-Antiplatelet Therapy After Drug-Eluting Stent Placement: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(2):118-126. doi:10.7326/M15-0083 Pooled risk for myocardial infarction with longer- versus shorter-duration DAPT after placement of a drug-eluting stent. See the legend for Figure 1 for abbreviation expansions. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

6. Date of download: 7/8/2016 From: Longer- Versus Shorter-Duration Dual-Antiplatelet Therapy After Drug-Eluting Stent Placement: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(2):118-126. doi:10.7326/M15-0083 Pooled risk for myocardial infarction with longer- versus shorter-duration DAPT after placement of a drug-eluting stent: subset analysis stratified by timing of randomization. See the legend for Figure 1 for abbreviation expansions. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

7. Date of download: 7/8/2016 From: Longer- Versus Shorter-Duration Dual-Antiplatelet Therapy After Drug-Eluting Stent Placement: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(2):118-126. doi:10.7326/M15-0083 Pooled risk for major bleeding with longer- versus shorter-duration DAPT after placement of a drug-eluting stent. See the legend for Figure 1 for abbreviation expansions. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

8. Date of download: 7/8/2016 From: Longer- Versus Shorter-Duration Dual-Antiplatelet Therapy After Drug-Eluting Stent Placement: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(2):118-126. doi:10.7326/M15-0083 Pooled risk for major bleeding with longer- versus shorter-duration DAPT after placement of a drug-eluting stent: subset analysis stratified by timing of randomization. See the legend for Figure 1 for abbreviation expansions. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

9. Date of download: 7/8/2016 From: Longer- Versus Shorter-Duration Dual-Antiplatelet Therapy After Drug-Eluting Stent Placement: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(2):118-126. doi:10.7326/M15-0083 Pooled risk for any stroke with longer- versus shorter-duration DAPT after placement of a drug-eluting stent. See the legend for Figure 1 for abbreviation expansions. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

10. Date of download: 7/8/2016 From: Longer- Versus Shorter-Duration Dual-Antiplatelet Therapy After Drug-Eluting Stent Placement: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(2):118-126. doi:10.7326/M15-0083 Pooled risk for revascularization with longer- versus shorter-duration DAPT after placement of drug-eluting stent. See the legend for Figure 1 for abbreviation expansions. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians