1. Date of download: 7/5/2016 Copyright © The American College of Cardiology. All rights reserved. From: Sex Differences in Hospital Mortality in Adults With Congenital Heart Disease: The Impact of Reproductive Health J Am Coll Cardiol. 2013;62(1):58-67. doi:10.1016/j.jacc.2013.03.056 Conceptual Model Illustrating the Primary Pathways and Intervening Factors Accounting for the Sex Distribution in the Demographics of the Population With CHD (A) Incident and prevalent CHD. (B) Surgical and medical outcomes. (C, D) Intervening pathways. CHD = congenital heart disease. Figure Legend:

2. Date of download: 7/5/2016 Copyright © The American College of Cardiology. All rights reserved. From: Sex Differences in Hospital Mortality in Adults With Congenital Heart Disease: The Impact of Reproductive Health J Am Coll Cardiol. 2013;62(1):58-67. doi:10.1016/j.jacc.2013.03.056 Most Relevant Cardiovascular Admission Diagnoses in Women and Men With Severe Defects, Stratified by Age Aortic comp = aortic complications including aneurysm, rupture, and bleeding; Arr/Cd = arrhythmia (ventricular/supraventricular)/conduction disturbances; CAD = coronary artery disease; CVA/TIA = cerebrovascular accident/transient ischemic attack; Endoc = endocarditis; HF = heart failure; Pulm HT = pulmonary hypertension; PM/prost = pacemaker or prosthetic implant-related diagnoses; Valve = valvular disease. *p < 0.05. Figure Legend:

3. Date of download: 7/5/2016 Copyright © The American College of Cardiology. All rights reserved. From: Sex Differences in Hospital Mortality in Adults With Congenital Heart Disease: The Impact of Reproductive Health J Am Coll Cardiol. 2013;62(1):58-67. doi:10.1016/j.jacc.2013.03.056 Direct Causes of 30-Day in-Hospital Deaths in Women (n = 90) and Men (n = 105) With CHD Age 18 to 45 Years Other main cardiac causes include congenital heart defect, endocarditis, myocardial infarction, pericardial disease, and pulmonary hypertension. Other vascular causes include mostly pulmonary embolism. Primary noncardiovascular causes include sepsis/infection, pneumonia, neurologic disease, and neoplasms. Figure Legend:

4. Date of download: 7/5/2016 Copyright © The American College of Cardiology. All rights reserved. From: Sex Differences in Hospital Mortality in Adults With Congenital Heart Disease: The Impact of Reproductive Health J Am Coll Cardiol. 2013;62(1):58-67. doi:10.1016/j.jacc.2013.03.056 RRs for 30-Day In-Hospital Mortality in Men Versus Women and in Men and Women With a Pregnancy History Versus Women Without Rate ratios (RRs) are presented after adjustment for age at admission, severity of defect, comorbidities, and admission diagnosis. In-hospital mortality in (A) men versus women and in (B) men and women with a pregnancy history versus women without. CI = confidence interval. Figure Legend: