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Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene by Christof Dame, Karin M. Kirschner, Katharina V. Bartz, Thomas.

Published byLydia Banks Modified over 8 years ago

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Presentation on theme: "Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene by Christof Dame, Karin M. Kirschner, Katharina V. Bartz, Thomas."— Presentation transcript:

1 Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene by Christof Dame, Karin M. Kirschner, Katharina V. Bartz, Thomas Wallach, Christiane S. Hussels, and Holger Scholz Blood Volume 107(11):4282-4290 June 1, 2006 ©2006 by American Society of Hematology

2 Binding of the Wt1(–KTS) isoform to the minimal human EPO promoter. Christof Dame et al. Blood 2006;107:4282-4290 ©2006 by American Society of Hematology

3 Activation of the minimal human EPO promoter by Wt1(–KTS) in U2OS cells. Christof Dame et al. Blood 2006;107:4282-4290 ©2006 by American Society of Hematology

4 Mutually enhanced binding affinities of Sp1 and Wt1(–KTS) to the human EPO promoter. Christof Dame et al. Blood 2006;107:4282-4290 ©2006 by American Society of Hematology

5 Induction of EPO expression by Wt1(–KTS) in human embryonic kidney (HEK293) and hepatoma- derived HepG2 cells. Christof Dame et al. Blood 2006;107:4282-4290 ©2006 by American Society of Hematology

6 Epo expression analysis in wild-type and Wt1-deficient mouse embryos. Christof Dame et al. Blood 2006;107:4282-4290 ©2006 by American Society of Hematology

7 Colocalization of Wt1 and EPO proteins in the developing murine dorsal root ganglion. Christof Dame et al. Blood 2006;107:4282-4290 ©2006 by American Society of Hematology

8 Colocalization of Wt1 and EPO in the adult murine testis. Christof Dame et al. Blood 2006;107:4282-4290 ©2006 by American Society of Hematology

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