1. Date of download: 7/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: The FRONTIER Stent Registry: Safety and Feasibility of a Novel Dedicated Stent for the Treatment of Bifurcation Coronary Artery Lesions J Am Coll Cardiol. 2005;46(4):592-598. doi:10.1016/j.jacc.2005.05.033 (A to E) Deployment sequence of the Frontier stent. (A) The system is advanced into the main branch over a conventional rapid- exchange wire. (B) The joining mandrel is retracted to release the over-the-wire side branch tip. A long guidewire is inserted into the side branch. (C) The system is advanced up to the carina. (D) With a single inflation device, the stent is deployed by kissing balloon inflation. (E) After deflation the delivery system is retracted. Figure Legend:

2. Date of download: 7/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: The FRONTIER Stent Registry: Safety and Feasibility of a Novel Dedicated Stent for the Treatment of Bifurcation Coronary Artery Lesions J Am Coll Cardiol. 2005;46(4):592-598. doi:10.1016/j.jacc.2005.05.033 Bifurcation lesion classification from the Duke University Angiographic Core Lab, Duke University, Durham, North Carolina. Type A: Prebranch stenosis not involving the ostium of the side branch. Type B: Postbranch stenosis of the parent vessel not involving the origin of the side branch. Type C: Stenosis encompassing the side branch but not involving the ostium. Type D: Stenosis involving the parent vessel and ostium of the side branch. Type E: Stenosis involving the ostium of the side branch. Type F: Stenosis directly involving the parent vessel and ostium of the side branch. Figure Legend:

3. Date of download: 7/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: The FRONTIER Stent Registry: Safety and Feasibility of a Novel Dedicated Stent for the Treatment of Bifurcation Coronary Artery Lesions J Am Coll Cardiol. 2005;46(4):592-598. doi:10.1016/j.jacc.2005.05.033 Kaplan-Meier curves: survival to 180 days, survival free of major adverse cardiac events (MACE), myocardial infarction (MI), and target lesion revascularization (TLR) (intent-to-treat population). Figure Legend: