1. caNanoLab Users Group  Building a collaborative environment enabling data sharing in the biomedical nanotechnology research community Oct. 17, 2008

2. 2 caNanoLab Users Group Agenda  Discuss caNanoLab 1.4.1 Project Status  Review caNanoLab 1.5 Wireframes/Requirements – Nanoparticle and Characterization Source – Assay Creation – Stability/Stressors – Instruments – Customized Logos/Conventions  Discuss Collaborations – NIST Nanobioinformatics Effort – Nanotechnology In Vivo Characterization Discussion Group

3. 3 caNanoLab 1.4.1 Project Status  caNanoLab 1.4.1 – Completed implementation of 1.4.1 features Merged publications and reports Added caching mechanism for grid location nodes Tested and resolved defects Completed model annotations and loaded into the caDSR Sandbox in support of grid services generation – Plan to deploy to QA: 10/21/2008 – Plan to complete caNanoLab 1.4.1: 11/3/2008  caNanoLab 1.5 – Drafted source wireframes – Drafted Assay Wireframes/Particle Stability  Other – Modified Wiki – Attended/demonstrated at NIST Nanoinformatics Planning Meeting – Continued In Vivo Characterization Working Group Coordination

4. 4 caNanoLab 1.5 Features GF#Feature Request 16523Add support for enhanced source metadata (investigators, manufacturers) 3826, 6192 Add support for stability/stressors (temperature, ph, freeze thaw, electromagnetic radiation, centrifugation, lyophilization, time) 4086Work with the CCNEs to determine valid values for specific data elements. Includes review/usage of updated Wash U ontology (NPO), and support for curated list of instruments/techniques. 15945Add select cross-reference IDs. Includes allowing user to enter PubChem IDs. 1216Allow users to create their own assays and characterizations (physical, in vitro, etc.) 6202, 16524 Add support for particle relaxivity 16525Enhance sequence field to support submission and validation of FASTA format 11565Allow laboratories to customize caNanoLab logos/color conventions (e.g. provide configurable border identifying laboratory) 9164Upgrade to the latest version of the CSM and caCORE SDK 3823Initiate requirements/design discussion of in vivo characterizations with the community

5. 5 #16523 - Support for Enhanced Source Metadata

6. 6 View Source Details

7. 7 Submit Source

8. 8 Characterization Source

9. 9 Search Nanoparticles by Source

10. 10 #1216 – Assay and Characterization Creation

11. 11 #3826, 6192 - Support for Stability/Stressors

12. 12 #4086 – Curated Instruments/Techniques DRAFT Instrument/Technique Concepts: https://gforge.nci.nih.gov/docman/view.php/69/14115/instrumentvstech nique08122008.xls

13. 13 Add New Instrument and Technique

14. 14 11565 – Customized caNanoLab Logos/Conventions Washington University in St. Louis

15. 15 NIST – Nanobioinformatics Effort  Collaborative effort to promote data and tool sharing in a federated approach  Participants include: – Data and Tool Sharing Providers – NanoHUB, caNanoLab, Knowledgebase of Nanomaterial-Biological Interactions (NBI), Internano – Organizations – NIST, NCI, NIBIB, NIOSH, NIEHS, FDA – Universities – UMass, Oregon State, Purdue – Other – Malvern, etc.

16. 16 NanoHUB  Web-based resource for research, education, and collaboration in nanotechnology  Hosts over 1300 resources (courses, modules, simulation tools, etc.)  Offers simulation tools that can be access from the web browser  Provides adapters for tool providers to wrap tools to operate within a web container  In the process of developing a cancer focused hub – Needs access to cancer nanotechnology data repositories (like caNanoLab)

17. 17 Internano  Portal serving the National Nanomanufacturing Network  Provides a repository of nanomanufacturing processes  Allows for the form-based submission of processes  Could be linked to caNanoLab Protocols

18. 18 Nanomaterial-biological Interactions (NBI) Knowledge Base  Sponsored by the US Air Force and EPA and developed by Oregon State  Provides analytical tools for comparing nanoparticles across research platforms  Provides access to Zebrafish toxicity data  Could be federated with caNanoLab  Visualization tools and concepts could be leveraged (along with visualization tools from GenePattern)

19. 19 NBI Search and Visualization Tools

20. 20 In Vivo Characterization Kickoff Meeting Agenda In Vivo Characterization Kickoff Meeting October 27, 2008 2:00-4:00 PM EST Agenda ItemTime Brief Overview of caNanoLab[2:00-2:15 PM] Discussion of In Vivo Characterization Discussion Group Goals [2:15-2:30 PM] Overview of In Vivo Characterizations (NCL)[2:00-2:20 PM] Overview of existing caNanoLab In Vivo Characterization Model and Wireframes [2:20-3:30 PM] Discuss Next Steps[3:30-4:00 PM]

21. 21 Potential In Vivo Characterization Participants OrganizationParticipants NCLAnil Patri, Marty Fritts, Steve Stern CTEP (Investigational Drug Branch, Translational Science Group) George Redmond, TBD NIBIBJames Luo, Lori Henderson NSTIPhil Lippel LASP (Transgenic Mouse Models)Sergeui Kozlov NCI Small Animal Imaging ProgramJoe Kalen NIEHSSally Tinkle caBIG Nanotech Working Group/CCNEsWash U, Stanford, GT, MIT OthersGov’t: NHLBI, NIAID, NAIC, NIH Clinical Center, FDA, EPA, NIOSH, DOE, NHGRI, NIST, National Labs, NCI Intramural Institutions: UC Davis, Purdue, Univ. of Michigan, Univ. of MD, Hopkins, Univ. of Chicago

22. 22 Updated Wiki

23. 23 caNanoLab Users Group Meeting Schedule  Monthly Telecons: – 3 rd Friday of Every Month – 1:30-2:30 PM EST – 1-800-FON-SAIC (1-800-366-7242) – Pass Code: 3321652# – Web Conference: http://www.saic.com/customer/datax/attendee.html Conference Ref: 54545 Attendee PIN: 8934  Next Meeting Date: November 21, 2008  caNanoLab Links: – Wiki: https://wiki.nci.nih.gov/display/ICR/caNanoLabhttps://wiki.nci.nih.gov/display/ICR/caNanoLab – GForge: http://gforge.nci.nih.gov/projects/calab/http://gforge.nci.nih.gov/projects/calab/ – NCL caNanoLab: http://cananolab.abcc.ncifcrf.gov/caNanoLab/ Thanks for Attending!