1. www.d3technologies.co.uk © 2008 D3 Technologies Ltd. All rights reserved. Private and Confidential. D3 Technologies – SERS products / solutions / services www.d3technologies.co.uk The Company Technology Klarite ™ Applications The D3 Technologies advantage SERS technology: delivering rapid trace level detection for Pharmaceutical Cleaning Verification

2. www.d3technologies.co.uk © 2008 D3 Technologies Ltd. All rights reserved. Private and Confidential. Formed in July 2007 Major investment by Renishaw plc, a worldwide leader in imaging & detection systems. Secure finances, avoiding the Venture Capitalist route R&D led, based at advanced research facility, Glasgow, UK Strong IP portfolio in our core technology based on Surface Enhanced Resonance Raman Spectroscopy: SERRS Company

3. www.d3technologies.co.uk © 2008 D3 Technologies Ltd. All rights reserved. Private and Confidential. Facilities 3000 sq metre facility Bio-labs for DNA analysis; Class100 Clean Room; Wet Chemistry, Colloid Prep and Spectroscopy suites

4. www.d3technologies.co.uk © 2008 D3 Technologies Ltd. All rights reserved. Private and Confidential. Surface Enhanced Raman Spectroscopy (SERS) What is it? SERS is an analytical technique for trace levels of soluble samples, providing information on molecular structure, identity and quantity

5. www.d3technologies.co.uk © 2008 D3 Technologies Ltd. All rights reserved. Private and Confidential. So Why SERS So why SERS? Capable of detecting analytes in parts per billion range – extreme sensitivity Directly applicably to wide sample range – flexible applications Target analytes give characteristic spectra – high specificity Short data collection times – rapid analysis Compatible with wide range of instrumentation – adaptable technology D3 Technologies has extensive experience of using SERS based methods for a wide range of applications, for everything from explosives detection to clinical diagnostics. D3 regularly undertake funded research programs for process development in a variety of fields.

6. www.d3technologies.co.uk © 2008 D3 Technologies Ltd. All rights reserved. Private and Confidential. Gold patterned surfaces – ~  m wells Semiconductor fabrication Proprietary engineering Customization possible Features Readiness commercially available off-the-shelf Certification in progress (ISO 9001) QMS/GMP Performance High reproducibility –RSD ~5% –batch-to-batch >10 yrs shelf life Demonstrated for –Small molecules –Proteins –Spores/viruses Klarite ® : substrates and technology

7. www.d3technologies.co.uk © 2008 D3 Technologies Ltd. All rights reserved. Private and Confidential. 1-2uL solution. Dilute solution to avoid bulk Raman: LOD as low as 1 ppb. Limit of detection is analyte dependent. 1. Deposition Klarite TM slide SERS active area sample pipette 2. Evaporation3. Measurement Experiments using Klarite

8. www.d3technologies.co.uk © 2008 D3 Technologies Ltd. All rights reserved. Private and Confidential. Bio-Pharmaceutical application – example MOLECULAR FINGERPRINT ANALYSIS OF MIXTURES 10 -3 M 10 -4 M 10 -5 M 10 -6 M QUANTIFICATION

9. www.d3technologies.co.uk © 2008 D3 Technologies Ltd. All rights reserved. Private and Confidential. Bio-Pharmaceutical application – example

10. www.d3technologies.co.uk © 2008 D3 Technologies Ltd. All rights reserved. Private and Confidential. Questions?