1. © Copyright 2004 Frost & Sullivan. All Rights Reserved. World Cardiac Rhythm Management Market Increased Clinical Trials and Technology Development Drives Growth in the Market Medical Devices Group “In the cardiac rhythm management (CRM) market, several important clinical trials have been conducted since 1996, which have helped identify more cases, thus expanding the pool of treatable patients. ”

2. © Copyright 2004 Frost & Sullivan. All Rights Reserved. Industry Trends Clinical trials identify patients, but technology drives growth. In the implantable cardioverter defibrillators (ICD) industry, two factors drive growth – advances in technology and clinical trials that expand the pool of treatable patients. Of the two, technological advances are disproportionately important. Several important clinical trials were conducted from 1996: MADIT (1996), AVID (1997), MUSTT (1999), MADIT II (2002), COMPANION (2003), DEFINITE (2003), SCD-HeFT(2003). The most important technological advancement in the early period was the introduction of dual-chambered ICDs in the fall of 1997. The big growth driver in the recent years was the 2002 launch of the biventricular pacing (cardiac resynchronization) ICD (CRT-Ds).

3. © Copyright 2004 Frost & Sullivan. All Rights Reserved. Key Features Frost & Sullivan Provides: Detailed insights into recent developments and trends Drivers, restraints, challenges, and strategic recommendations Analyst insights on emerging technologies and applications in the CRM market Market sizing and competitive analysis Market forecasts and opportunity analysis SWOT analysis for companies and technologies

4. © Copyright 2004 Frost & Sullivan. All Rights Reserved. What We Offer Global Coverage: The United States, Europe, Asia Pacific, and Rest-of-World Proven methodology encompassing extensive primary and secondary data and research Focused information and strategies that cover business and technology issues Credible data and analysis highlighting industry dynamics Winning strategies to help you create precise business plans

5. © Copyright 2004 Frost & Sullivan. All Rights Reserved. Who Will Benefit? Current Market Participants Find out how you compare to the competition Assess current and future drivers and restraints Determine and exploit market share opportunities New Entrants Analyze challenges associated with the industry Calculate forecasts for end-user growth potential Position yourself to capitalize on the market’s unmet needs Investment Community Analyze long-term strategies of companies Determine which participants will outperform the competition Assess attractiveness of investing in the market

6. © Copyright 2004 Frost & Sullivan. All Rights Reserved. What’s Included Drivers, restraints, and trends Top companies Challenges faced Unit shipments and pricing forecasts Forecasts for pacemakers, ICD and CHF devices for each geography Analysis of emerging products and technology

7. © Copyright 2004 Frost & Sullivan. All Rights Reserved. Key Market Participants Medtronic, Inc. Guidant Corp. St. Jude, Inc. Biotronik Sorin Biomedica Ela Medical Japanlifeline

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