1. Build your own DNA 1.Get one nitrogen bases sheet, one railing sheet, one blank sheet, 6 colors and a glue stick or tape. 2.Color nitrogen bases FIRST – as shown on p 291 3.Color “railings” in two different colors, one for the Deoxyribose sugar and one for the Phosphate. 4.Cut out railings parts loosely. (Cut only 1/2 the sheet for now – keep the other half for later.) 5.Lay out railing parts tightly onto sheet, making two columns on opposite sides, alternating Deoxyribose-Phosphate-Deoxyribose-Phosphate, etc. 6.Get approval from teacher 7.Glue railings down 8.Cut out nitrogen bases loosely. (Cut only 1/2 the sheet for now – keep the other half for later.) 9.Lay out nitrogen base pairs on sheet in RANDOM order between Deoxyribose sugar molecules, being sure to keep the appropriate nitrogen base pairs together. (refer to textbook p 294) 10.Get approval from teacher 11.Glue nitrogen base pairs and draw connecting lines from them to the Deoxyribose sugar molecules on each side. Note: You will have extra nitrogen bases. Keep them for later. 12.Put your names on back of sheet and turn in.

2. Nitrogen bases G A T C G A T C G A T C G A T C G A T C G A T C G A T C G A T C

3. Sugar and Phosphate Railing/Backbone D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P D P

4. DNA replication 1.“Unzip” your DNA molecule by cutting down the center of your DNA model between each nitrogen base pair (where the hydrogen bond would be). 2.Glue a new colored sheet between the open nitrogen base edges of your existing half sheets to make space for new nucleotides. 3.Color your new nitrogen bases to match the original colors and cut them out loosely. 4.Glue the new nitrogen bases next to the original ones onto the middle sheet, following the base-pairing rule. 5.Color the deoxyribose and phosphates to match your original colors and cut out. 6.Glue the two new “railings” down. 7.Draw lines connecting the nitrogen base pairs to the Deoxyriboses. 8.Answer the questions shown on projector reflectively somewhere on back. 9.Make sure your names are still showing on the back, get checked off by the teacher, and use masking tape to put it up on the wall in the classroom.

5. DNA Replication Questions Which DNA strands are the “parent” strands? Are your new DNA strands exact replicas of the original parent strand? Explain.