1. Date of download: 6/26/2016 Copyright © The American College of Cardiology. All rights reserved. From: Assessing the Risk of Progression From Asymptomatic Left Ventricular Dysfunction to Overt Heart Failure: A Systematic Overview and Meta-Analysis JCHF. 2016;4(4):237-248. doi:10.1016/j.jchf.2015.09.015 Study Selection Process Flowchart showing search strategy for published data and selection process for inclusion of studies in the systematic review. Figure Legend:

2. Date of download: 6/26/2016 Copyright © The American College of Cardiology. All rights reserved. From: Assessing the Risk of Progression From Asymptomatic Left Ventricular Dysfunction to Overt Heart Failure: A Systematic Overview and Meta-Analysis JCHF. 2016;4(4):237-248. doi:10.1016/j.jchf.2015.09.015 Meta-Analysis: Prevalence of LVSD in 6 Cohorts Forest plot showing the overall estimate of the prevalence of left ventricular systolic dysfunction (LVSD) in 6 cohorts included in meta-analysis. CI = confidence interval; EF = ejection fraction. Figure Legend:

3. Date of download: 6/26/2016 Copyright © The American College of Cardiology. All rights reserved. From: Assessing the Risk of Progression From Asymptomatic Left Ventricular Dysfunction to Overt Heart Failure: A Systematic Overview and Meta-Analysis JCHF. 2016;4(4):237-248. doi:10.1016/j.jchf.2015.09.015 Incident Congestive Heart Failure Event Rates Among Individuals With LVSD or LVDD and Control Subjects LVDD = left ventricular diastolic dysfunction; PY = person-year; other abbreviations as in Figure 2. Figure Legend:

4. Date of download: 6/26/2016 Copyright © The American College of Cardiology. All rights reserved. From: Assessing the Risk of Progression From Asymptomatic Left Ventricular Dysfunction to Overt Heart Failure: A Systematic Overview and Meta-Analysis JCHF. 2016;4(4):237-248. doi:10.1016/j.jchf.2015.09.015 Meta-Analysis: Association of Asymptomatic LVSD and Incident Clinically Overt Heart Failure (Maximal Adjustment) Forest plot showing the overall maximally adjusted estimate of the association of asymptomatic LVSD and incident clinically overt heart failure. RR = relative risk; other abbreviations as in Figure 2. Figure Legend:

5. Date of download: 6/26/2016 Copyright © The American College of Cardiology. All rights reserved. From: Assessing the Risk of Progression From Asymptomatic Left Ventricular Dysfunction to Overt Heart Failure: A Systematic Overview and Meta-Analysis JCHF. 2016;4(4):237-248. doi:10.1016/j.jchf.2015.09.015 Meta-Analysis: Association of Asymptomatic LVDD and Incident Clinically Overt Heart Failure (Maximal Adjustment) Forest plot showing the overall maximally adjusted estimate of the association of asymptomatic LVDD and incident clinically overt heart failure. Abbreviations as in Figures 2 and 3. Figure Legend: