1. Dial-a-Molecule Annual Meeting Monday 2nd July Warwick University

2. Vision: In 20-40 years, scientists will be able to deliver any desired molecule within a timeframe useful to the end-user, using safe, economically viable and sustainable processes. Delivery of novel molecules should be as quick and efficient as it currently is for stock chemicals. How can we make novel molecules in DAYS not YEARS?

3. Aims of Initial Network Funding Produce a roadmap defining a route to the Grand Challenge Start to develop the cross-disciplinary groups to tackle the challenge. Develop a profile for Dial-a-Molecule

4. Current network structure Grand Challenge Steering GroupFocusing our efforts advisory group Themes Initial focus areas Lab of the future and Synthetic Route Selection A Step Change in Molecular Synthesis Catalytic paradigms for 100% efficient synthesis Smart Laboratory Optimum Reaction and Route Design Reaction Analysis Next Generation Reaction Platforms Multi- Dimensional Catalysis Target Driven Catalysis Understanding Catalysis Holistic Synthesis Perfect Reactions

5. 1. Lab of the Future and Synthetic Route Selection (RJW)  Optimum Reaction and Route Design (Champions: Frank Langbein, Sophie Schirmer)  The Smart Laboratory (Champion: Richard Whitby)  Next Generation Reaction Platforms (Champion: Harris Makatsoris).  Reaction analysis (Champion: Alison Nordon) 2. A Step Change in Molecular Synthesis (DH)  Stepwise perfection (1000 Click Reactions) (Champion: Andrew Russell)  Holistic approach to molecular synthesis (Champion: Donald Craig) 3. Catalytic paradigms for 100% efficient synthesis (SM)  Engineering control through fundamental mechanistic understanding (Champion: Joe Sweeney)  Intervention-free synthesis by phase-distinct, multi-dimensional catalysis (Champion: Robin Bedford)  New reactivity: target-driven catalysis (Champion: Matthew Cook) Network themes and focus areas

6.  Selectivity, Sustainability, Predictability: Multi-Disciplinary Issues for 21st Century Catalysis. 7 th /8 th July 2011, AstraZeneca Alderley Park.  Optimum Reaction and Route Design 25 th /26 th July 2011, Jealott’s Hill  The Smart Laboratory 28/29 th July 2011, Southampton  A Step Change in Synthesis 2 nd /3 rd August 2011, AstraZeneca, Macclesfield  Next Generation Reaction Platforms. 11/12 th August 2011, GSK, Stevenage.  Reaction analysis 7/8 th September 2011, University of Strathclyde. Meetings / Workshops that provided the principal inputs to the roadmap

7. Summary of other activities Web sites (www.dial-a-molecule.org and on Connect_) Monthly newsletters Network of more than 400 researchers with around 38% from industry. 58% of academic members are from outside of synthetic chemistry Additional Meetings: Data Exchange Format (Southampton, Dec 9 th 2011 Focusing our Efforts Industrial advisory group Roadmap Review Feb 20 th 2012) Synthetic Chemistry for the Life Sciences (Liverpool, 11 th Jan, 2012) Using Synthetic Biology to Dial-a-Molecule (GSK, June 19th, 2012) National pilot of the iLabber Electronic Laboratory Notebook (March – Sept 2012)

8. Report and Draft Roadmap submitted to EPSRC November 2011. Positive feedback from panel Case for Three year Network Submitted March 2012 Funded April 2012 - March 2015 Final (initial) version of roadmap published Today.

9. Report and Draft Roadmap submitted to EPSRC November 2011. Positive feedback from panel Case for Three year Network Submitted March 2012 Funded April 2012 - March 2013 Final (initial) version of roadmap published Today.

10. Aims of Network extension Deliver the ‘near term’ objectives of the Dial-a-Molecule Roadmap. Facilitate funding of relevant work Drive step change in ambition in synthesis Promote change in synthesis to being data-driven making full use of automation Horizon scanning and new collaborations Build a sustainable Grand Challenge Community Deliver economic and societal impact from the Grand Challenge Raise the profile of the Grand Challenge beyond Community members

11. Mechanisms for delivery of aims Meetings & Sandpits - fund travel and accommodation. Theme and annual meetings - fund meeting cost. Interdisciplinary mobility fund – travel and accommodation Bursaries for ECRs Funding for educational activities Funding for small studies and proof of concept studies.

12. Mechanisms for delivery of aims Sandpit meetings- fund travel and accommodation. Theme and annual meetings - fund meeting cost. Interdisciplinary mobility fund – travel and accommodation Bursaries for ECRs Funding for educational activities Funding for small studies and proof of concept studies.

13. Aims for Today Launch the Roadmap and 2 nd Phase of Network Initiate requests for funding from the network. Help to plan network activities for the next year. Form groups to take various aspects of Dial-a-Molecule forward

14. The Roadmap Lab of the Future and Synthetic Route Selection (RJW) A Step Change in Molecular Synthesis. (Prof. David Harrowven) Catalytic Paradigms for Efficient Synthesis (Prof. Steve Marsden)

16. Lab of the Future and Synthetic Route Selection Optimum Reaction and Route Design (Frank Langbein, Sophie Schirmer) Smart Laboratory (RJW) Next Generation Reaction Platforms (Harris Makatsoris ) Rapid Reaction Analysis (Alison Nordon )

17. Key Challenge: Prediction of the outcome of unknown reactions

18. 10.15 -10.45 Key Roadmap outputs from the theme areas (RJW, David Harrowven, and Steve Marsden) 10.45- 11.00 Roadmap economic impact and funding opportunities (Steve Hillier, Chemistry Innovation) 11.00 - 11.10 EPSRC perspective and funding opportunities (Alex Berry) 11.10 - 12.10 (or so) The ‘National Electronic Laboratory Notebook’ initiative (RJW) Towards freely accessible data: Automated extraction of reaction and spectroscopic data from thesis. (Peter Murray-Rust). Dial-a-Molecule and Synthetic Biology (Joe Sweeney and Dave Hollingshead). Next Generation Reaction Platforms (Harris Makatsoris) Reagentless Synthesis (Andy Russell) Materials Science and Dial-a-Molecule (Mike Shipman) Barriers to the uptake of new reactions by industry (David Fox) Inventing new reactions with impact (Anne Horan) The 3D-fragment consortium (Andy Morley) National Centre for Reaction study (RJW)