1. Date of download: 6/21/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Cost-effectiveness Analysis of Herpes Simplex Virus Testing and Treatment Strategies in Febrile Neonates Arch Pediatr Adolesc Med. 2008;162(7):665-674. doi:10.1001/archpedi.162.7.665 Components of the decision tree used in the cost-effectiveness analysis of herpes simplex virus (HSV) testing and treatment strategies in neonates with fever. CNS represents central nervous system; SEM, skin, eyes, and mouth. For neurodevelopmental outcome; see “Quality-Adjusted Life Expectancies” subsection of the “Methods” section. Figure Legend:

2. Date of download: 6/21/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Cost-effectiveness Analysis of Herpes Simplex Virus Testing and Treatment Strategies in Febrile Neonates Arch Pediatr Adolesc Med. 2008;162(7):665-674. doi:10.1001/archpedi.162.7.665 One-way sensitivity analysis of herpes simplex virus (HSV) infection prevalence for the cost-effectiveness of testing and empirically treating HSV in febrile neonates. CSF represents cerebrospinal fluid; ICER, incremental cost-effectiveness ratio; PCR, polymerase chain reaction; QALY, quality-adjusted life-years. Figure Legend:

3. Date of download: 6/21/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Cost-effectiveness Analysis of Herpes Simplex Virus Testing and Treatment Strategies in Febrile Neonates Arch Pediatr Adolesc Med. 2008;162(7):665-674. doi:10.1001/archpedi.162.7.665 One-way sensitivity analysis of herpes simplex virus (HSV) test cost for the cost-effectiveness of testing and empirically treating HSV in febrile neonates. The entire cost of testing was varied so that the polymerase chain reaction (PCR) was the only cost varied for the HSV PCR test strategy, and the entire cost of all tests included in the comprehensive testing was varied for the comprehensive testing strategy. CSF represents cerebrospinal fluid; ICER, incremental cost-effectiveness ratio; QALY, quality- adjusted life-years. Figure Legend:

4. Date of download: 6/21/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Cost-effectiveness Analysis of Herpes Simplex Virus Testing and Treatment Strategies in Febrile Neonates Arch Pediatr Adolesc Med. 2008;162(7):665-674. doi:10.1001/archpedi.162.7.665 One-way sensitivity analysis of number of hospital days elapsed while awaiting herpes simplex virus (HSV) test results for the cost- effectiveness of testing and empirically treating HSV in febrile neonates. CSF represents cerebrospinal fluid; ICER, incremental cost-effectiveness ratio; PCR, polymerase chain reaction; QALY, quality-adjusted life-years. Figure Legend:

5. Date of download: 6/21/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Cost-effectiveness Analysis of Herpes Simplex Virus Testing and Treatment Strategies in Febrile Neonates Arch Pediatr Adolesc Med. 2008;162(7):665-674. doi:10.1001/archpedi.162.7.665 Probabilistic sensitivity analysis: cost-effectiveness acceptability curves. CSF represents cerebrospinal fluid; ICER, incremental cost-effectiveness ratio; QALY, quality-adjusted life-years. Figure Legend: