1. © NIH National Center for Image-Guided Therapy, June 2008 Slicer IGT Nobuhiko Hata, PhD Sandy Wells, PhD Computation Core, NCIGT

2. © NIH National Center for Image-Guided Therapy, June 2008 Updates from NCIGT Year 4 Intra-operative application – Interactive tractography in brain surgery – Intra-operative use of B-spline deformable registration for CT-guided liver and kidney therapies Dissemination events using completed Slicer IGT tutorial set

3. © NIH National Center for Image-Guided Therapy, June 2008 Interactive Tractography in brain surgeries Use tracking device to – Seed tractography at the location of neurosurgical lesion – Examine location of critical fiber tract near the lesion to avoid neurological defect Collaboration with Neurosurgery Core, Brain Lab, Xenios Papademetris (R01EB000473) Five cases performed as of today.

4. © NIH National Center for Image-Guided Therapy, June 2008

5. Intra-operative image fusion in CT- guided ablation therapies Global motion of the liver/kidney modeled with Affine Registration B-Spline interpolation model for local deformation of the tissue Registration between multiple modalities (MR – CT, CT – CT) Applied to 25 liver and kidney cases Collaboration with Dr. Silverman (BWH) and Dr. Cleary (Georgetown)

6. © NIH National Center for Image-Guided Therapy, June 2008 Pre-procedure contrast Enhanced MRI Intra-procedure planning CT Registered and Fused MR-CT images Segmented tumor on CT with probes positioned Segmented tumor on CT with ice ball 3D evaluation of ablation procedure CTg Liver Cryotherapy

7. © NIH National Center for Image-Guided Therapy, June 2008

8. New Slicer Functions from IGT Hepatics Interface (Jayender Jagadeesan, BWH) CUDA volume rendering for 3D+t ultrasound integration (Jan Grumprecht, BWH, Danielle Pace, UWO, Nicholas Herlabang, Univ. Tokyo) Second Display (Andras Lasso, Queens Univ, Junichi Tokuda, BWH) Open IGT Link (Matlab)