1. Varian Medical Systems
Particle Therapy GmbH
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2. 1948 Company founded in 1948 by Russell and Sigurd Varian
Varian Medical Systems
A Reliable Partner in Proton Therapy
Company founded in 1948 by Russell and Sigurd Varian
Over 2 billion USD in yearly revenues
Over 6 billion USD market capitalization
5,700 employees world-wide
55% market share in global radiation oncology market
1948
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3. Varian Medical Systems Product Portfolio – Integrated System Solutions
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4. History of Proton Program
Commitment
History of Proton Program
1992 Varian Develops Proton Treatment Planning
1997 Varian Provides Information Systems for Proton Centers
2007 Varian Purchases ACCEL Instruments
2007 Isochronous Superconducting Cyclotron becomes clinical at PSI
2009 Complete Treatment System Delivered to Rinecker Proton Center Munich, Germany (>1200 patients)
2011 First US ProBeam System Delivered to Scripps Health in San Diego
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5. Varian Proton Therapy Projects
Project Update
Varian Proton Therapy Projects
Scripps PT Center
Equipment order finalized/booked Q4 FY11
3 Rotational and 2 Fixed Beam Rooms
KFMC-King Fahd Medical Center
Equipment Order finalized/booked Q2 FY12
3 Rotational and 1 Fixed Beam & 1Eye Tx
St Petersburg, Russia
2 Rotational Gantries
Univ. of Maryland
4 Rotational and 1 Fixed Beam Rooms
Ground breaking occurred April 2012
Georgia Proton Treatment Center (Emory)
Purchase Agreement under negotiation
4 Rotational and 1 Fixed Beam Room
Signed contract for Mestre, Italy
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6. Proton Platform—Overview
ProBeam™
Proton Platform—Overview
Dynamic PeakTM Scanning
Superconducting Cyclotron
Big Bore Beam Line
2D Orthogonal & CBCT
Eclipse & ARIA Integration
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7. Why a Cyclotron? Compact & simple
ProBeam™ Accelerator System
AC 250 Cyclotron
Why a Cyclotron?
Compact & simple
Continuous, high intensity beam (IMPT)
Low activation (Service)
Reproducible behavior (Operations)
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9. Dynamic PeakTM Scanning
ProBeam™
Dynamic PeakTM Scanning
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10. Dynamic Peak™ Scanning Specifications
Range: Up to 37.6 g/cm2
Field size at isocenter: Up to 30 x 40 cm2
Dose compliance: Better than ±2.5%
Dose rate: Variable with a maximum of 2 Gy/min in 1 liter volume
Layer repainting
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11. IMPT Summary Quality of Care Optimum dose conformity
Dynamic Peak™ Scanning
Intensity Modulated Proton Therapy
IMPT
Summary
Quality of Care
Optimum dose conformity
Allows adaptive treatments and integrated boosts
Workflow
Increased efficiency
Shorter and more stable treatment times
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12. Advanced Development Role and Responsibilities:
Developments with high research content
Contacts and collaborations with institutes
Upcoming new concepts new technologies
Patents
Technology input to strategic planning
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13. Development Example Development of the 250 MeV ProBeam cyclotron
Teams:
National Superconducting Cyclotron Lab, Michigan University, US - Baseline design and sc cyclotron design expertise
Paul Scherrer Institute, Villigen, CH - First customer, cyclotron operation expertise
Kernfysisch Versnelleren Instituut, Groningen, NL, Operation of sc cyclotrons
Varian/Accel team, Project management, Regulatory compliance, detailed engineering design teams
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14. Development example Development Process: Design Implementation
Test V&V
Concept
Joined design team at NSCL
Commissioning and testat PSI
Detailed design at Varian
Fabrication
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15. Regulatory Compliance
For CE marking
Establish certified Quality Management System according to ISO
Engage Notified Body for the assessment of conformity with the requirements of the European Medical Device Directive 93/42/EWG
Prepare Documentation of Design and Manufacturing Process.
Continuous review of product documentation
with the Notified Body
Final audit of product and documentation
Receive approval from Notified Body to declare CE conformity
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16. Marketing challenges Financing Cost of equippment Cost of building
Time to first patient
patients per day
Operating cost
"Integrate into normal Radiation Therapy"
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17. Call for Ideas & Research
Accelerator - Cost, Size, Weight, Beam duty factor
Gantry - Cost, Size, Weight
Beamline - Cost, Size, Weight
Scanning - Speed
Commissioning - Automation
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18. Thank you!
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19. ProBeam™ Accelerator System AC 250 Cyclotron -- Specifications
Beam - Energy 250 MeV
Extracted current (max) 800 nA
Extraction efficiency ~80%
Iron Yoke - Outer diameter 3.1 m
Height 1.6 m
Weight 90 t
SC Magnet - Stored energy 2.5 MJ
Central field 2.4 T
Max. field at the coil 4 T
Operating current 160 A
Power of cryocoolers 40 kW
RF System - Frequency 72.8 MHz
Voltage 80 kV / 130 kV
RF power ≤115 kW
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