2. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. Data as of July 2015 101 million+ uniquely identified organic and inorganic Substances The largest collection of small molecules –by tens of millions– available anywhere 81 million+ Reactions Nearly double the next largest reaction source 41 million+ Literature References Plus integrated access to 24 million records in the MEDLINE ® database from the U.S. National Library of Medicine 63 Patent Authorities 25% more than any other scientific information provider CAS analyzes the world’s disclosed research to keep SciFinder the most valuable tool supporting your organization’s research enterprise gives you access to the world’s most authoritative disclosed chemistry content.

3. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. Training and customer support included as part of the experience Continuous improvements in SciFinder capabilities CAS adds value to your SciFinder experience, keeping up with the accelerated pace of disclosed research CAS keeps pace, providing the highest standards of quality and timeliness Global research continues to expand, notably literature published in Asia Complexity of intellectually analyzed content is growing Rate of disclosed chemistry continues to accelerate Research Trends CAS Response

4. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. The rapid acceleration of disclosed research drives content growth in the CAS databases Information added to the CAS databases annually since 2000

5. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. CAS actively curates millions of content additions every year July 2014 Markush structures 1,043K Regulated chemicals 311K Commercially available products 65M Reactions 73M Organic/Inorganic Substances 89M Citations 404M References 39M July 2015 41M 448M 101M 81M 105M 344K 1,089K Content 1 Year Growth

6. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. Content additions over the past three years add significant value to your SciFinder experience! Content July 2012 Markush structures 939K Regulated chemicals 295K Commercially available products 69M Reactions 58M Organic/Inorganic Substances 67M Citations 333M References 36M 3 Year Growth July 2015 41M 448M 101M 81M 105M 344K 1,089K

7. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. CAS provides comprehensive coverage of science disclosed in a variety of scientific disciplines and publications

8. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. Biology –Biochemistry –Cell –Journal of Biological Chemistry –Journal of Cell Biology –Journal of Experimental Biology –FASEB Journal –Proceedings of the National Academy of Sciences –Lancet –Journal of the American Medical Association –Nature –Science Analytical Chemistry –Analytical Chemistry –Annual Review of Analytical Chemistry –Biosensors and Bioelectronics –TrAC – Trends in Analytical Chemistry –Journal of Chromatography A –Electrochemistry Communications –Analytica Chimica Acta –Electrochimica Acta Polymer and Material Science –Advances in Polymer Science –Chemistry of Materials –Macromolecules –Carbon –Wiley Interdisciplinary Reviews: Computational Molecular Science –Progress in Polymer Science –Progress in Solid State Chemistry –Macromolecular Bioscience –Macromolecular Rapid Communications –Nature Nanotechnology –Progress in Materials Science –Nano Letters CAS coverage includes publications scientists read daily across the spectrum of scientific disciplines

9. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. New layout and format greatly improves readability and user-friendliness of substance detail pages New table view provides easier and faster access to the commercial source data PatentPak TM Efficient access to the most requested patents in SciFinder 1.4 million experimental spectra >100,000 protons and carbon-13 NMR additions > 4.5 million experimental properties Addition of >67,000 single-step reactions and their experimental procedures from 1,450 dissertations in SORD SciFinder saves you time by delivering valuable information to advance your research 6.5 million+ experimental reaction procedures with 1.2 million added in the last year alone!

10. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. CAS scientists curate chemical information using standardized terminology to help researchers quickly find the most relevant search results in SciFinder

11. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. CAS scientists find the chemistry, and save you time! CAS RN 203796-03-6

12. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. Unlike its competitors, CAS covers patents in many languages, with enhanced translations

13. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. Increasingly, new chemical compounds in the literature are first disclosed in patents Use to gain immediate access to patents in a unique interactive viewer.

14. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. SciFinder allows you to explore and analyze the breadth of CAS content so you can be more effective in your work Quickly find and analyze information (research topic, structure, reaction) Stay current in your field and keep track of competition Share ideas with colleagues and collaborators

15. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. SciFinder enables you to choose global commercial sources of fine chemicals that are geographically convenient Commercial Source Locations

16. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. Global regulatory information in SciFinder supports your commerce requirements Did you know CAS maintains the TSCA inventory for the U.S. EPA? 0 20 40 60 80 100 120 140 IN THOUSANDS CAS RNs GLOBAL REGULATORY INVENTORIES REACH – Europe EINECS – Europe TSCA – USA NDSL – Canada ENCS – Japan IECSC –China AICS – Australia ECL – Korea NZIOC – New Zealand DSL – Canada PICCS – Philippines SWISS – Switzerland ELINCS – Europe

17. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. Recent enhancements to SciFinder ensure efficient access to CAS content and increase research productivity Ease of use A functional new layout of substance detail improves your efficiency Streamlined authentication reduces tedious repetitive logins Workflow Access SciFinder from within ChemDraw ® API access better integrates SciFinder into the researcher’s workflow Productivity Identify reagents for experiments via reagent analysis tool Easily set preferred or non-preferred commercial sources Faster access to the commercial source data with new table view PatentPak – Save up to 50% of your time spent evaluating patents

18. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. Only, a robust patent workflow solution, allows you to track down the relevant chemistry in the patents you need in half the time  Instant access to searchable full-text patents from major patent offices around the world  Patent family coverage in multiple languages  Secure and confidential patent research  Daily updates  Interactive viewer with substance location mapping and built-in SciFinder search functionality

19. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. Organizations around the world rely on SciFinder The top 100 universities in the world 48 of the top 50 pharmaceutical companies globally 24 of the top 25 biotechnology companies globally 47 of the top 50 chemical companies worldwide The top CROs in India The top U.S. government organizations The largest consortium and top research facilities in China The largest consortia in Asia Europe, Latin America and North America is used by… Sources: - The Academic Ranking of World Universities - Chemical & Engineering News - Genetic Engineering & Biotechnology News - PharmaExec.com

20. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. Renowned scientists trust SciFinder for research in scientific disciplines beyond traditional chemistry “SciFinder, in the past, had the reputation of being primarily chemistry-focused, but this is no longer the case. In fact, SciFinder covers a multitude of different scientific fields. It covers chemistry; it covers biology and pharmacology. And from my perspective in drug discovery, importantly, it covers many other branches of the life sciences. I use it as much for biology as I do for chemistry.” Dr. Nick Terrett Chief Scientific Officer of Ensemble Therapeutics

21. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. “I can find information in SciFinder that I can’t seem to find anywhere else. If it’s not in SciFinder, it probably doesn’t exist.” Robert Koechley Director of Information Management Promega Corporation “Without SciFinder, we are blind. Our business would not exist.” Jiang Shenji Head of domestic development PharmaResources Co. (Shanghai) Ltd. A. Douglas Kinghorn, PhD Editor-in-Chief Journal of Natural Products The Ohio State University “Without SciFinder, it’s impossible to properly do our work in natural products. It’s become absolutely essential and saves us so much time” Others agree: SciFinder is critical for trusted research

22. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. SciFinder training is available in a variety of options and media types – Learn the way you prefer SciFinder training is regularly updated and provided at no additional charge. Short “Need to Know” videos and introductory tutorials in English, Spanish, Chinese and Portuguese Redesigned How-to guides available in English and Japanese Recorded e-Seminars on topics related to synthetic chemistry, structure drawing, polymers and patents Resources for SciFinder trainers Introductory virtual class recordings

23. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. The CAS Customer Center is staffed by scientists available to answer your questions and provide quality support in a variety of areas and subjects How do I find patents covering specific polymers used in medical devices ? ? How can I verify that my drug lead is not under patent already How do I find the latest developments in green energy research ? We do more than just answer questions – we’re your partner in advancing your research.

24. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. Industry leader in comprehensiveness, timeliness and quality Can be used for a wide variety of scientific research needs Powerful and easy to use Content expertly curated by the best scientists SciFinder saves your organization time and money If you’re not using SciFinder, you’re missing valuable information! Trust your results. Others have learned the hard way.

25. CAS is a division of the American Chemical Society. Copyright 2015 American Chemical Society. All rights reserved. Improved accuracy, security, peace of mind Multi-year agreements offer the lowest SciFinder rates and efficient management benefits for your organization Most attractive renewal rates Reduce frequency of renewal discussions Predictable budgeting Spend more time on research Maximize your return on investment

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