1. Date of download: 6/3/2016 From: Radial Versus Femoral Access in Invasively Managed Patients With Acute Coronary Syndrome: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(12):932-940. doi:10.7326/M15-1277 Summary of evidence search and selection. Selection process for studies to be included in the meta-analysis in compliance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) standards. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 6/3/2016 From: Radial Versus Femoral Access in Invasively Managed Patients With Acute Coronary Syndrome: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(12):932-940. doi:10.7326/M15-1277 Risk of bias in the studies included in the meta-analysis. Plus sign denotes low risk. Minus sign denotes high risk. MATRIX = Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX; RIFLE-STEACS = Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome; RIVAL = A Trial of Trans-radial Versus Trans-femoral Percutaneous Coronary Intervention Access Site Approach in Patients With Unstable Angina or Myocardial Infarction Managed With an Invasive Strategy; STEMI-RADIAL = Trial Comparing Radial and Femoral Approach in Primary Percutaneous Coronary Intervention. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 6/3/2016 From: Radial Versus Femoral Access in Invasively Managed Patients With Acute Coronary Syndrome: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(12):932-940. doi:10.7326/M15-1277 Meta-analysis of radial versus femoral access for access-site crossover. MATRIX = Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX; RIFLE-STEACS = Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome; RIVAL = A Trial of Trans-radial Versus Trans-femoral Percutaneous Coronary Intervention Access Site Approach in Patients With Unstable Angina or Myocardial Infarction Managed With an Invasive Strategy; RR = relative risk; STEMI-RADIAL = Trial Comparing Radial and Femoral Approach in Primary Percutaneous Coronary Intervention; W = weight. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 6/3/2016 From: Radial Versus Femoral Access in Invasively Managed Patients With Acute Coronary Syndrome: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(12):932-940. doi:10.7326/M15-1277 Meta-analysis of radial versus femoral access for all-cause mortality and MACE. The forest plots show a 27% RR reduction in mortality and a 14% RR reduction in MACE with radial compared with femoral access. MACE = major adverse cardiovascular events; MATRIX = Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX; RIFLE-STEACS = Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome; RIVAL = A Trial of Trans-radial Versus Trans-femoral Percutaneous Coronary Intervention Access Site Approach in Patients With Unstable Angina or Myocardial Infarction Managed With an Invasive Strategy; RR = relative risk; STEMI- RADIAL = Trial Comparing Radial and Femoral Approach in Primary Percutaneous Coronary Intervention; W = weight. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5. Date of download: 6/3/2016 From: Radial Versus Femoral Access in Invasively Managed Patients With Acute Coronary Syndrome: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(12):932-940. doi:10.7326/M15-1277 Meta-analysis of radial versus femoral access for access-site and major bleeding. The forest plots show a 64% RR reduction in access-site bleeding and a 43% RR reduction in major bleeding with radial compared with femoral access. MATRIX = Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX; RIFLE-STEACS = Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome; RIVAL = A Trial of Trans-radial Versus Trans-femoral Percutaneous Coronary Intervention Access Site Approach in Patients With Unstable Angina or Myocardial Infarction Managed With an Invasive Strategy; RR = relative risk; STEMI-RADIAL = Trial Comparing Radial and Femoral Approach in Primary Percutaneous Coronary Intervention; W = weight. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

6. Date of download: 6/3/2016 From: Radial Versus Femoral Access in Invasively Managed Patients With Acute Coronary Syndrome: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(12):932-940. doi:10.7326/M15-1277 Meta-analysis of radial versus femoral access for myocardial infarction and stroke. MATRIX = Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX; RIFLE-STEACS = Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome; RIVAL = A Trial of Trans-radial Versus Trans-femoral Percutaneous Coronary Intervention Access Site Approach in Patients With Unstable Angina or Myocardial Infarction Managed With an Invasive Strategy; RR = relative risk; STEMI-RADIAL = Trial Comparing Radial and Femoral Approach in Primary Percutaneous Coronary Intervention; W = weight. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians