1. MICROBIOLOGIA GENERALE
Viral replication

2. Possible cytopathogenesis of cells infected with animal viruses

3. The reproductive cycle of animal viruses
Virus attachment to host cell
Virus entry into cells
Transcription, translation and genome replication
Assembly, exit and maturation of progeny virions

4. ATTACHMENT PENETRATION VIRAL SYNTHESIS UNCOATING ASSEMBLY EXIT
TRANSCRIPTION
UNCOATING
TRANSLATION
REPLICATION
ASSEMBLY
(MATURATION)
EXIT

5. virus attachment to host cells
Viral replication
virus attachment to host cells

6. Viral receptors and coreceptors

7. Influenza virus structure

8. virus entry into host cells
Viral replication
virus entry into host cells

9. Three entry and uncoating strategies

10. Mechanism of uncoating within endosomes

11. Virus entry via receptor-mediated endocytosis

12. transcription, translation and genome replication
Viral replication
transcription, translation and genome replication

13. Genomes of DNA viruses
unimolecular
ds or ss
5-240 kb
linear or circular
Genomes of RNA viruses
unimolecular or segmented
ss or ds
1,7-25 kb
linear or circular
(+ )or (-) polarity

14. The diversity of viral transcription strategies
Synthesis of viral macromolecules
The diversity of viral transcription
strategies
The diversity of viral translation
strategies
The diversity of viral genome replication strategies

15. The diversity of viral transcription and translation strategies: Rhabdoviruses (-) ssRNA

16. The diversity of viral translation strategies: Picornaviruses polyprotein synthesis

17. The diversity of viral genome replication strategies: adenovirus DNA replication

18. The Baltimore classification system
Class I and VII
ds DNA

19. The Baltimore classification system
Class I and VII
ds DNA
Class II
ss DNA

20. The Baltimore classification system
Class I and VII
ds DNA
Class II
ss DNA
Class III
ds RNA (+/-)

21. The Baltimore classification system
Class I and VII
ds DNA
Class II
ss DNA
Class III
ds RNA (+/-)
Class IV
ss RNA (+)

22. The Baltimore classification system
Class I and VII
ds DNA
Class II
ss DNA
Class III
ds RNA (+/-)
Class IV
ss RNA (+)
Class V
ds RNA (-)

23. The Baltimore classification system
Class I and VII
ds DNA
Class II
ss DNA
Class III
ds RNA (+/-)
Class IV
ss RNA (+)
Class V
ds RNA (-)
Class VI

24. The Baltimore classification system
Parvovirus
(B19)
Class I and VII
ds DNA
Class II
ss DNA
Class III
ds RNA (+/-)
Class IV
ss RNA (+)
Class V
ds RNA (-)
Class VI
Adenovirus
Herpesvirus
Papilloma
Polyomavirus
Poxvirus
Hepadnavirus
Retrovirus
Orthomyxovirus
Paramyxovirus
Rhabdovirus
Reovirus
Picornavirus
Togavirus

25. transcription, translation and genome replication of DNA viruses
Viral replication
transcription, translation and genome replication of DNA viruses

27. Flow of events in multiplication of Herpeviruses:
an example Class I virus
Figure: 16-20
Caption:

28. Structure and genome organization of Herpes simplex 1 virus (HSV-1)

29. Attachment
Entry
Uncoating
Viral
Synthesis
Assembly
Maturation
Exit

30. Structure and genome organization of the Poxvirus Vaccinia virus: an example of Class I virus that replicates in the cytoplasm

31. Attachment
Entry
Uncoating
Viral
Synthesis
Assembly
Maturation
Exit

32. transcription, translation and genome replication of RNA viruses
Viral replication
transcription, translation and genome replication of RNA viruses

34. V IV
III

35. Structure and genome organization of the Picornavirus Poliovirus: an example of Class IV virus

36. Attachment
Entry
Uncoating
Viral
Synthesis
Assembly
Maturation
Exit

37. Poliovirus RNA replication

38. Structure and genome organization of the Rhabdovirus Vesicular Stomatitis Virus: an example of Class V virus

39. Attachment
Entry
Uncoating
Viral
Synthesis
Assembly
Maturation
Exit

40. The Orthomyxovirus Influenza A virus: an example of Class V virus that replicates in the nucleus

41. Attachment
Entry
Uncoating
Viral
Synthesis
Assembly
Maturation
Exit

42. Class VI virus: the Retroviruses

43. Attachment
Entry
Uncoating
Viral
Synthesis
Assembly
Maturation
Exit

44. Replication process of a Retrovirus

45. Replication process of a Retrovirus

46. Translation of Retrovirus mRNA and processing of the proteins: the GAG and POL proteins

47. Translation of Retrovirus mRNA and processing of the proteins: the ENV proteinsSU TM

48. Structure and genome organization of the Class VII virus: Hepadnaviruses

50. Attachment
Entry
Uncoating
Viral
Synthesis
Assembly
Maturation
Exit

51. assembly, exit and maturation of progeny virions
Viral replication
assembly, exit and maturation of progeny virions

52. Hypothetical pathway of virion assembly and release

53. Assembly of Poliovirus in the cytoplam of an infected cell

54. Assembly of a Retrovirus from polyprotein precursors

55. Mechanism of budding of enveloped viruses