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By: Victoria Roman Dr. Hobbs Biology P.6 May 15, 2004
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500 400 300 200 100 TreatmentsGene Therapy History Types of Hemophilia Clotting Process
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Categories The body goes under three processes of clotting to do this. Clotting Process 100 Points
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Categories Clotting Process 100 Points What is stop the bleed?
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Categories Clotting Process 200 Points This process is the narrowing of blood vessels to decrease the flow of blood.
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Categories What is vasoconstriction? Clotting Process 200 Points
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Categories Clotting Process 300 Points Platelets attach themselves to one another with this sticky material.
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Categories Clotting Process 300 Points What is von Willebrand’s factor?
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Categories What is the purpose of fibrin? Clotting Process 400 Points
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Categories Fibrin, a thicky threadlike substance, forms a mesh over the platelets and pulls everything tightly together. Clotting Process 400 Points
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Categories What are the three processes the body goes under to stop the bleeding? Clotting Process 500 Points
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Categories First is vasoconstriction, next is a platelet plug formation, lastly, a fibrin clot formation is built. Clotting Processes 500 Points
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Categories What is the most common type of Hemophilia? Types of Hemophilia 100 Points
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Categories Types of Hemophilia 100 Points What is Type A?
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Categories Types of Hemophilia 200 Points Hemophilia A is caused by a deficiency in what factor?
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Categories What is Factor XIII? Types of Hemophilia 200 Points
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Categories Types of Hemophilia 300 Points Hemophilia B was named after whom?
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Categories Types of Hemophilia 300 Points Who is Steven Christmas?
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Categories Hemophilia B is due to a lack of this certain factor. Types of Hemophilia 400 Points
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Categories What is Factor IX. Types of Hemophilia 400 Points
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Categories Hemophilia C affects how many people? Types of Hemophilia 500 Points
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Categories What is one in every one hundred people? Types of Hemophilia 500 Points
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Categories Hemophilia is often called the “_____ disease” because is spread throughout the ruling families of Europe and Russia. History 100 Points
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Categories History 100 Points What is the royal disease?
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Categories History 200 Points In 1932, R.G MacFarlane, a British pathologist, first learned that this unusual treatment helped blood clot.
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Categories What is viper venom or commercialized “Stypen” which is still used today. History 200 Points
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Categories History 300 Points Who was Queen Victoria’s son that had hemophilia and died at the age of thirty-one from bleeding in the head after a minor fall?
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Categories History 300 Points Who is Prince Leopold?
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Categories In the early 1950’s, scientists used injections of blood plasma from what two animals to help hemophiliacs? History 400 Points
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Categories What are cows and pigs? History 400 Points
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Categories Who performed the first successful blood transfusion for postoperative bleeding in a little boy with hemophilia? History 500 Points
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Categories Who is Samuel Lane, an English physician? History 500 Points
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Categories What are genes? Gene Therapy 100 Points
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Categories Gene Therapy 100 Points What are specific sequences of bases that encode instructions on how to make proteins?
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Categories Gene Therapy 200 Points Gene therapy is a technique for doing what?
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Categories What is for correcting defective genes responsible for disease development? Gene Therapy 200 Points
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Categories Gene Therapy 300 Points An abnormal gene could be swapped for a normal gene through this approach.
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Categories Gene Therapy 300 Points What is homologous recombination?
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Categories Factors that have kept gene therapy from becoming an effective treatment for genetic diseases are immune response, problems with viral infectors, multigene disorders, and ______________. Gene Therapy 400 Points
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Categories What is the short-lived nature of gene therapy? Gene Therapy 400 Points
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Categories Name four of the different types of viruses used as gene therapy vectors. Gene Therapy 500 Points
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Categories What are retroviruses, adenoviruses, adeno-associated viruses, and herpes simplex viruses? Gene Therapy 500 Points
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Categories What four treatment preparations that contain clotting factor are used by hemophiliacs? Treatments 100 Points
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Categories Treatments 100 Points What are whole blood, plasma, cryoprecipitate, and factor concentrates? (also desmopressin or DDAVP and Gene Therapy)
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Categories Treatments 200 Points What are some drawbacks for cryoprecipitate?
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Categories Treatments 200 Points What are that it is less safe from viral contamination than concentrates and is harder to store and administer?
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Categories Treatments 300 Points What are some drawbacks in using whole blood in the treatment of hemophilia?
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Categories What are that the whole blood must be fresh, the red cells most be compatible with the recipient, and the possibility of overloading the circulation and causing the heart to fail? Treatments 300 Points
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Categories In plasma, the life of the clotting factor is preserved by making this product. Treatments 400 Points
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Categories What is fresh frozen plasma or FFP? Treatments 400 Points
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Categories This percentage of the people with hemophilia in the world receive treatment. Treatments 500 Points
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Categories What is 25%? Treatments 500 Points
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Categories http://www.wfh.orghttp://www.wfh.org/ShowDoc.asp?Rubrique=28&Docu ment=42 www.icondata.com/health/pedbase/files/HEMOPHIL.ht m http://www.wfh.org/ShowDoc.asp?Rubrique=28&Docu ment=328 http://www.hemophiliagalaxy.com www.hemophilia.net http://www.ucsfhealth.org/childrens/medical_services?ca ncer/hemophilia/conditions/hemo/signs.html http://www.wfh.org/ShowDoc.asp?Rubrique=28&Docu ment=335 http://www.kelleycom.com www.hog.org/hemophilia.htm http://www.hemophilia.com http://www.novoseven.com/content/useful_information/ wfh_leaflet?wfh_leaflet.asp Linker, Charles A. 2002 Current Diagnosis and Treatment Magalini, Sergio L., and Sabrina C. Magalini Dictionary of Medical Syndromes Vol.4 Willet, Edward Hemophilia Key NS, Aledort LM, Beardsley, et al. “Why do people with hemophilia bleed?”
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