1. MUSC Biomedical Trainee Retreat on the Responsible Conduct of Research Feb 12, 2016 “Collaborative Research” Ed Krug, PhD Professor of Regenerative Medicine and Cell Biology Medical University of South Carolina krugel@musc.edu

2. Think of a past collaboration… How did it develop? What were the outcomes? What assumptions did you make at the onset? What do you wish you had done differently?

3. Related to your current research… How might a collaborator accelerate your current research? Where might you look to find that person?

5. Team Science is the “new” norm https://www.teamsciencetoolkit.cancer.gov/pu blic/Home.aspx http://www.teamscience.net/

6. Collaborative research – same discipline either intra- or inter-institutional Example: serving as Co-PI or Co-investigator on an R01/R21 Multidisciplinary research – crosses different disciplines either intra- or inter-institutional Example: serving as Co-PI/Co-I on an R01 OR having a component in a consortium/center Different types of team science

7. The Multi-PI Leadership Plan should include the following: A rationale for choosing a multiple PD/PI approach should be described The governance and organizational structure of the leadership team and the research project should be described, including communication plans process for making decisions on scientific direction procedures for resolving conflicts The roles and administrative, technical, and scientific responsibilities for the project or program should be delineated for the PD/PIs and other collaborators If budget allocation is planned, the distribution of resources to specific components of the project or the individual PD/PIs must be delineated NIH Multi-PI Grant Requirements

8. Bottom lines for effective collaborations Communication from beginning to end Establish individual roles and expectations at the onset Identify a data retention plan Agree on reagent distribution Discuss authorship at the onset and throughout but don’t be unrealistic about your contribution Discuss intellectual property issues at the onset Establish who is in charge – and who will be the responsible agent

9. What are the scientific issues, goals, and anticipated outcomes? When is the project over? Do all members of the research team agree on these issues? What are the expected contributions of each participant? Who will write any progress reports and final reports? How will you decide about redirecting the research agenda? How will you ensure that all appropriate members are kept fully informed? How will you negotiate the development of new collaborations or projects? How and by whom will personnel be supervised? What will be the criteria and the process for assigning authorship and credit? How will credit be attributed to each collaborator's institution for public presentations, abstracts, and written articles? How and by whom will public presentations be made? How and by whom will media inquiries be handled? When and how will you handle intellectual property and patent applications? How and by whom will data be managed? How will access to data be managed? How will you handle long-term storage and access to data after the project is complete? Should one of the principals of the research team move to another institution or leave the project, how will you handle, data, specimens, lab books, and authorship and credit? http://ori.dhhs.gov/education/preempt_discord.shtml Core Issues of Collaborations

10. Where and When? Conferences Social networks Departmental meetings/seminars/journal clubs How? Come with a clear hypothesis/objective and timeline for a PILOT study (ask the same of those that approach you) Vet that person Previous collaborators productivity

11. ... They might last 1 or 2 dates... They might last for decades... They might end in divorce

12. “People Issues” in Research Collaborations Are the researchers well suited for the collaboration? Do participants have appropriate experience and training? Do the participants have a proven track record of accomplishments? Does the collaboration bring together individuals with complementary and integrated expertise? Are the different leadership styles of participants compatible? How will reviewers view my role in resulting publications? How does my intended collaborator view my qualifications?

13. Jung Typology Test (“MBTI-like”) http://www.humanmetrics.com/cgi-win/jtypes2.asp

14. Introversion (I) Extraversion (E) Sensing (S) Intuition (N) Thinking (T) Feeling (F) Judging (J) Perceiving (P) source of energy preference for taking in information decision making dealing with the outside world

18. NCI Team Science Toolkit - https://www.teamsciencetoolkit.cancer.gov/public/Home.aspx https://www.teamsciencetoolkit.cancer.gov/public/Home.aspx Northwestern University COALESCE: Team Science - http://www.teamscience.net/http://www.teamscience.net/ Data Management Plan Tool - https://dmp.cdlib.orghttps://dmp.cdlib.org Dougsguides: Conflict Resolution Style Assessment - http://www.dougsguides.com/conflict_style http://www.dougsguides.com/conflict_style National Center for Professional & Research Ethics (video case study) - https://nationalethicscenter.org/resources/42 https://nationalethicscenter.org/resources/42 Northern Illinois University Faculty Development and Instructional Design Center Responsible Conduct in Collaborative Research Modules - http://ori.hhs.gov/education/products/niu_collabresearch/collabresearch/collabobj ectives.html http://ori.hhs.gov/education/products/niu_collabresearch/collabresearch/collabobj ectives.html Collaborative Research Simulation - http://ori.dhhs.gov/education/products/niu_collabresearch/collabresearch/overvie w/overview.html http://ori.dhhs.gov/education/products/niu_collabresearch/collabresearch/overvie w/overview.html RESOURCES