1. BONE PLUS ORIFERA EDUCATION SERIES

2. Osteoporosis is called a “silent “ disease because it is often diagnosed only after a person suffers a fracture.

3. However, you don’t have to wait till then to find out you are losing your bones.

4. Bone formation and depletion is a natural condition of life, but as age increases bone depletion accelerates much faster than its formation often due to insufficient ionised calcium storage.

5. Osteoporosis can be a particular problem for Asian women, who in general have less bone mass than females of other races, and thus are more vulnerable to bone mass loss. 52% of Asian women aged 50 and above are estimated to have low bone mass. 35% of Asian men aged 50 and above are estimated to have low bone mass.

6. Bone reaches its maximum mass by age 25 to 30. After that, bone mass begins to decline gradually. As for women, loss of bone is dramatically accelerated during the first 5 to 10 years after menopause when women can lose as much as 30% of their skeleton!” – University of Pittsburgh Medical Centre

7. Calcium is one of the most important and irreplaceable minerals because of its role in :- Formation and growth of bones and teeth Maintenance of strong bones and teeth and Protection from increasing bone loss due to ageing.

8. Do you know that 1 out of 3 women and 1 out of 5 men around the world are affected by osteoporosis.

9. What are the signs of osteoporosis ? Wrist pain Low back pain Hip pain Gradual loss of height (Pants looking longer or losing 4 to 6 inches in height. Cramps in the legs at night Neck pain Fatigue Brittle fingernails Bone fracture Slooped posture

10. Causes of osteoporosis:- Old age Estrogen deficiency Lack of exercise Poor diet / nutritional deficiency Heavy smoking Heavy drinking Taking too much steroids.

11. You are never too old to improve your bone health The good news is that you are never too old or too young to improve your bone health. There are many things you can do to keep bones strong and prevent fractures. At all ages, a diet with enough calcium and vitamin D, together with weight-bearing physical activity every day, can prevent problems later.

12. Bones are living organs Bones are living organs. They are alive with cells and flowing body fluids. Bones are constantly renewed and grow stronger with a good diet and physical activity.

13. Bones and teeth make up 99% of calcium Calcium is the most common mineral in the human body.mineral About 99% of the calcium in the body is found in bones and teeth, while the other 1% is found in the blood and soft tissue.

14. BONE PLUS

15. Bone Plus is a nutraceutical product for those suffering from osteoporosis.

16. Who needs Bone Plus ?. Those who suffer from the following symptoms. Wrist pain Low back pain Hip pain Gradual loss of height (Pants looking longer or losing 4 to 6 inches in height. Cramps in the legs at night Neck pain Fatigue Brittle fingernails Bone fracture Slooped posture

17. 7 dehydrocholesterol Solar UV B (290 -315 nm) and heat Provit D3 >> previt D3 >>> Vit D3 25(OH) D 1,25 (OH)2D 1 α, 25 (OH) hydroxylase PARATHYROID GLAND Calcitonin Osteoblast > osteoclast i.e. increased bone density HOW DO BONE PLUS WORKS ? Bone Plus

18. Osteoclastsare bone-resorbing cells ("-clast" means to break; osteoclasts break down bone). They are large, multinucleate cells that form through the fusion of precursor cells. Unlike osteoblasts, which are related to fibroblasts and other connective tissue cells, osteoclasts are descended from stem cells in the bone marrow that also give rise to monocytes. Osteoblastsare bone-forming cells. They are connective tissue cells found at the surface of bone. They can be stimulated to proliferate and differentiate as osteocytes. Osteocytesare bone cells. Osteocytes manufacture type I collagen and other substances that make up the bone extracellular matrix. Osteocytes will be found enclosed in bone. TYPES OF BONE CELLS

19. BONE PLUS INGREDIENTS NoName of ingredient 1Calcium L lactate 2Lactose 3Fructo oligosaccharides 4Inulin 5L- lysine 6L-proline 7L-cysteine 8Vitamin C 9Alpha Lipoid acid 10Calcium premix 11Vitamin D3 12Omega 3 13Bromelain

20. Recommended daily intake in women older than 50 years SourceCalciumVitamin D3 2006 Malaysian Clinical Practice Guidelines Recommendations for Elderly Population 1000 mg/day800 IU/day 2008 National Osteoporosis Foundation Recommendations for Adults 50 Years and Older 1200 mg/day800 -1000 IU/day For more information, please visit www.nof.org/prevention/calciumwww.nof.org/prevention/calcium and vitamin D.htm

21. A high prevalence of vitamin D inadequacy was seen across all all geographic regions Geographic regionsPercentage of vitamin D inadequacy America53.4 % Europe57.7% Middle East81.8% Asia71.4% Australia60.3% World average64.92% Vitamin D inadequacy defined by a serum 25(OH) D level < 30 ng/mL.

22. Conclusion If you find that your bones are becoming weaker, there are things you can do to make them stronger. You can be more physically active, change your diet, and take Bone Plus