1. Date of download: 5/29/2016 From: A Cost Analysis of Alternative Treatments for Duodenal Ulcer Ann Intern Med. 1995;123(9):665-672. doi:10.7326/0003-4819-123-9-199511010-00004 Decision tree for the treatment of duodenal ulcer.2RA2Helicobacter pylori2Helicobacter pyloriThe decision tree identifies decision alternatives and their clinical outcomes. H equals treatment with an H -receptor antagonist alone; HpRx equals treatment with antibiotics for infection plus an H -receptor antagonist; HP equals. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 5/29/2016 From: A Cost Analysis of Alternative Treatments for Duodenal Ulcer Ann Intern Med. 1995;123(9):665-672. doi:10.7326/0003-4819-123-9-199511010-00004 Two-way sensitivity analysis showing the average direct cost per ulcer cure as a function of the prevalence of Helicobacter pylori for each initial strategy.2RA2Helicobacter pylori2Repeat endoscopy is the secondary strategy for ulcer recurrence. The two broken vertical lines delineate three areas in which the least costly initial strategy is shown. H equals treatment with an H -receptor antagonist alone; HpRx equals treatment with antibiotics for infection plus an H -receptor antagonist; urease equals urease test-based treatment. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 5/29/2016 From: A Cost Analysis of Alternative Treatments for Duodenal Ulcer Ann Intern Med. 1995;123(9):665-672. doi:10.7326/0003-4819-123-9-199511010-00004 Three-way sensitivity analysis comparing initial treatment with an H 2 -receptor antagonist alone and initial treatment with antibiotics for Helicobacter pylori infection plus an H 2 -receptor antagonist.H. pyloriH. pylori22H. pylori2This analysis shows the threshold for long-term cure when the prevalence of infection is 70% to 100%. Secondary treatment is antibiotics for infection plus an H -receptor antagonist. Base-case point is the open circle at the intersection of the two broken lines. H2RA equals H -receptor antagonist; HpRx equals antibiotics for infection plus an H -receptor antagonist. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 5/29/2016 From: A Cost Analysis of Alternative Treatments for Duodenal Ulcer Ann Intern Med. 1995;123(9):665-672. doi:10.7326/0003-4819-123-9-199511010-00004 Three-way sensitivity analysis comparing urease test-based treatment and treatment with antibiotics for Helicobacter pylori infection plus an H 2 -receptor antagonist as initial treatment.2H. pylori2H. pyloriH. pylori22H. pylori2This analysis shows the thresholds for costs of treatment with an H -receptor antagonist alone and treatment with antibiotics for infection plus an H -receptor antagonist when the prevalence of is 70% to 100%. Secondary treatment is antibiotic treatment for infection plus an H -receptor antagonist. Base-case point is the open circle at the intersection of the two broken lines. H2RA equals H -receptor antagonist; HpRx equals antibiotics for infection plus an H -receptor antagonist. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians