1. 3 April 2003 Treatment as prevention: why? Gus Cairns Editor, HIV Treatment Update

2. 24 November 2010 NAT Treatment as Prevention HIV diagnoses

3. 24 November 2010 NAT Treatment as Prevention Condom use in UK gay men

4. 24 November 2010 NAT Treatment as Prevention Treatment as prevention: evidence? Montaner, Lancet 376: 532 – 539, 2010

5. 24 November 2010 NAT Treatment as Prevention BC study again

6. 24 November 2010 NAT Treatment as Prevention San Francisco Das-Douglas, CROI 2010, abstract #33

7. 24 November 2010 NAT Treatment as Prevention What would it take in San Francisco? In San Francisco 85.5% are diagnosed of whom 78% are linked to care of whom 90% are on ARVs of whom 72% are undetectable = 43.2% of people with HIV in San Francisco have an undetectable viral load (due to treatment)

8. 24 November 2010 NAT Treatment as Prevention Imperial College mathematical model Getting 80% of people with CD4 under 350 on treatment would be enough to reduce transmission by >90% if: Lower-risk pops tested every 2-3 years High-risk pops test every 6m Dodd PJ, Garnett GP, Hallett TB. Examining the promise of HIV elimination by 'test and treat' in hyperendemic settings. AIDS 24: 729-735, 2010

9. 24 November 2010 NAT Treatment as Prevention A wild card: PrEP IPrEx study, results 2 days ago 44% efficacy on 51% adherence Potentially 70-90% efficacy: cf condoms Practical? Affordable? Applicable? Dangerous? We may need to start thinking of ARVs-as-prevention for HIV-negative as well as HIV- positive people ?Pilot study of ARV treatment for high-risk HIV-negative testers nested within TasP project? Grant RM et al. Preexposure chemoprophylaxis for HIV prevention in men. New Engl Jour Med 23 November 2010.