1. Dae-Hyun Kim (danny@catholic.ac.kr) Dept. of Biomedical Engineering The Catholic University of Korea Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital 의료 분야에서의 G EANT 4 활용 (2)

2. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital 1.Proton Treatment Nozzle 2.Medical LINAC 3.DICOM Interface 4.TPS and MC Analysis Toolkit Contents

3. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital Proton Therapy Facility in NCC Proteus 235 Specification Weight : 220 ton Height : 210 cm Diameter : 434 cm Energy : 230MeV (Fixed) Max. extracted beam current : 300nA RF frequency :106 MHz

4. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital Proton Nozzle Scanning Magnet 1 st Ion Chamber 1 st Scatterer 2 nd Scatterer Range Modulator Variable Collimator SnoutSnout 2 nd & 3 rd Ion Chamber Aperture & Compensator Compensator

5. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital Modeling of Proton Nozzle

6. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital 1 st and 2 nd Scatterer

7. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital 1 st and 2 nd Scatterer #User Interface /GTR2/FS/lollipops FSID /GTR2/FS/all in /GRT2/FS all out #User Interface /GTR2/FS/lollipops FSID /GTR2/FS/all in /GRT2/FS all out #User Interface /GTR2/SS/select SSID #User Interface /GTR2/SS/select SSID

8. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital Range Modulator and Snout

9. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital Range Modulator and Snout #User Interface /GTR2/RM/track RMID /GTR2/RM /angle deg #User Interface /GTR2/RM/track RMID /GTR2/RM /angle deg #User Interface /GTR2/SNT/type Sount ID /GTR2/SNT position cm /GTR2/SNT fully_retract /GTR2/SNT fully_extract #User Interface /GTR2/SNT/type Sount ID /GTR2/SNT position cm /GTR2/SNT fully_retract /GTR2/SNT fully_extract

10. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital Validation  Pristine Bragg-peak

11. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital  Spread-out Bragg-peak (SOBP) Validation 15 X 15 Voxelized Water Phantom

12. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital  Specific Geometry of the Patient Aperture and Compensator Milling machineRTPG EANT 4

13. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital Application

14. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital 1.Proton Treatment Nozzle 2.Medical LINAC 3.DICOM Interface 4.TPS and MC Analysis Toolkit Contents

15. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital

16. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital Modeling of the LINAC TargetTarget Primary Collimator Multi-leaf Collimator MirrorMirror CollimatorCollimator Flattening Filter CarouselCarousel

17. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital Modeling of the LINAC CarouselCarouselJawJaw CollimatorCollimatorGantryGantry

18. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital 1.Proton Treatment Nozzle 2.Medical LINAC 3.DICOM Interface 4.TPS and MC Analysis Toolkit Contents

19. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital  Patient geometry  Patient scanned data from CT in DICOM format  Each CT is assigned to a voxel  3D Reformation / 2D Clustering of voxels  HU – Material Table DICOM-Interface

20. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital  Tissue materials are categorized into 24 groups  The paper gives the conversion table from HU value to the mass density and element weight. Conversion of HU to Materials W. Schnider et al., Phys. Med. Biol. 45 (2000) 459

21. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital  DICOM data files  CT images data set  *.dcm  A list of DICOM files Input Files for DICOM data

22. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital  DICOM data files  CT images data set  *.dcm  A list of DICOM files  Density conversion table  Data file for converting HU number to mass density Input Files for DICOM data

23. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital  DICOM data files  CT images data set  *.dcm  A list of DICOM files  Density conversion table  Data file for converting HU number to mass density  Material mapping table  Materials corresponding to CT ranges Input Files for DICOM data

24. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital G EANT 4-Dicom Interface CT Scanner CT Data Set G EANT 4 Geometry GDD Data

25. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital  In order to display the G EANT 4 output  Volume data (including overlay of more than one set)  Trajectories  Geometry  Runs on:  Windows, Linux and Mac  Based on a commercial package but offered freely to all G EANT 4 users  Download  http://geant4.kek.jp/gMcren/ gMocren

26. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital 1.Proton Treatment Nozzle 2.Medical LINAC 3.DICOM Interface 4.TPS and MC Analysis Toolkit Contents

27. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital  By execution, G EANT 4 creates a output file (GDD format)  This file includes below…  Data of the patient  Calculated dose distribution  Particle trajectories  Shape of modulse of the beam irradiation system GDD Output

28. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital  Developed based on DICOM-pyler  Written in python language  Function  Visualize CT data set and simulated geometry  Dose distribution  Analysis and comparison of dose distribution TPS and MC Analysis Toolkit

29. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital TPS and MC Analysis Toolkit TPS MC Doss diff. Gamma Index  Plan Evaluation  Dose Differencae  Gamma Index  Dose Volume Histogram  Plan Evaluation  Dose Differencae  Gamma Index  Dose Volume Histogram

30. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital TPS and MC Analysis Toolkit TPS MC  Plan Evaluation  Dose Differencae  Gamma Index  Dose Volume Histogram  Plan Evaluation  Dose Differencae  Gamma Index  Dose Volume Histogram

31. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Seoul St. Mary’s Hospital TPS and MC Analysis Toolkit  Plan Evaluation  Dose Differencae  Gamma Index  Dose Volume Histogram  Plan Evaluation  Dose Differencae  Gamma Index  Dose Volume Histogram

32. Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Medicine The Catholic University of Korea Dae-Hyun Kim danny@catholic.ac.kr Thank you for your attention ! The Catholic University of Korea Seoul St. Mary’s Hospital