1. TechKnowledge Sales Meeting 18 February 2016 Mark Schregardus Founder & CEO

2. Founded in summer 2013 Products: o Transplant Library o Transfusion Evidence Library o Child Abuse Atlas  Child Abuse Evidence  The Quarterly Update  Interactive Workbooks o KSR Pain Evidence o Under development: Nutrition Evidence

3. The Information Challenge we Solve 1.Quantity: o ~600,000 publications on “transplantation” o ~13,000 publications in 2015 o ~2,240 publications in June o ~ 70 new publications every day! 2.Quality: different levels of evidence 3.Relevancy 4.Interpretation: the value of expert opinions

4. The “Evidence Pyramid” High-level evidence: ~10,000 publications* ~600,000 publications* * Transplantation Medicine example

5. Evidence-based information on Organ Transplantation

6. The definitive resource for all high quality, evidence-based information on all aspects of solid organ transplantation, combined with Expert Reviews from recognized subject matter experts

7. Produced by the Centre for Evidence in Transplantation (CET) Founded & Directed by Professor Sir Peter Morris (Transplant Celebrity) Promoting an evidence-based approach to clinical practice, and good quality research Endorsed and supported by leading transplant societies: Middle East Society for Organ Transplantation (MESOT) TOND (Turkish Society) European Society for Organ Transplantation (ESOT) British Transplant Society Canadian Transplant Society Brazil Transplant Society Officially endorsed by the Cochrane Collaboration

8. All evidence-based publications on organ transplantation Randomized Controlled Trials & Systematic Reviews “Expert Reviews” written by subject matter experts, focus on impact on clinical practice Expert Reviewers from MEA Professor Hatem Khalaf (Hamad Medical Corporation) Professor Riadh A. S. Fadhil (Qatar Organ Donation Center) Professor Yasser Hammad (Hamad Medical Corporation) Professor Nabil Mohsin (SQU / Royal Hospital Oman) Clinical Practice Guidelines CET Conclusions assessment of the quality and conclusions of the study

10. RCTs are critically appraised Methodological quality score Clinical Impact Rating for reviewed studies Practice Changing Studies highlighted Funding Information: Industry Funded / Non-Industry Funded Trial Registration Information Direct access to free & subscribed full text articles

13. Key User Benefits Access to all evidence-based publications in one place Experts provide a practical interpretation of the ever increasing volume and complexity of evidence Clinical Practice Guidelines assessed on their level of evidence An automatic “Alerting Service” (Personal Evidence Update) for newly available evidence relevant to you => EASY TO SELL!!

14. TARGET CUSTOMERS 1.All Transplant Centers Mediclinic City Hospital – Dubai Al Maktoum Medical Library – Dubai Healthcare City SKMC & Cleveland Clinic – Abu Dhabi SQU – Royal Hospital Oman 2.Organ Procurement / Donation Centers SCOT - Saudi Center for Organ Transplantation  SUPER TARGET! MoH Kuwait Organ Procurement 3.Transplantation Societies 4.Pharma Companies 5.Hospitals (Nephrologists)

15. Evidence-based information on Transfusion Medicine

16. The definitive resource for all high quality, evidence-based information on all aspects of transfusion medicine, combined with Clinical Commentaries from recognized subject matter experts => potential impact on clinical practice!

17. Produced by the NHS Blood and Transplant – Systematic Review Initiative & the UK Blood Services Officially endorsed by the Cochrane Collaboration All evidence-based publications on all aspects of transfusion medicine Systematic Reviews since 1950 Randomized Controlled Trials (RCTs) since 1990 Relevant Health Economic Evaluations since 1980 “Clinical Commentaries” Written by subject matter experts Focus on impact on clinical practice Personal Evidence Alert

20. TEL database – User Benefits Very easy and reliable access to the best available evidence in transfusion medicine Experts provide a practical interpretation of the ever increasing volume and complexity of evidence An automatic “Alerting Service” (Personal Evidence Update) for new relevant evidence, based on your personal profile

21. TARGET CUSTOMERS 1.(National) Blood Transfusion Centers Sharja Blood Transfusion and Research Center Dubai Blood Donation Center (DHA) Saudi Society of Transfusion Medicine HMC Kuwait Central Blood Bank Khoula Hospital & Royal Hospital Oman NBTS / MoH Oman (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847343/)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847343/ Dr. Sanmukh R. Joshi, Institute of Health Sciences, moc.oohay@jhkumnas 2.Blood Transfusion Societies 3.Pharma / Corporate 4.All Medical Schools (TM program) & all hospitals

22. Evidence Summaries & Critical Appraisals of best available evidence on all aspects of Pain KSR Pain Evidence

23. The only information resource in pain medicine that critically appraises all best available evidence (systematic reviews & clinical practice guidelines) on all areas of pain KSR Pain Evidence

24. The “Evidence Pyramid” High-level evidence

25. Content development: Kleijnen Systematic Reviews (KSR) Ltd. Founded by Professor Jos Kleijnen, MD, PhD Director, Kleijnen Systematic Reviews Ltd Professor of Systematic Reviews in Health Care, Maastricht University Clinical Professor, Joanna Briggs Institute, University of Adelaide Independent research company based in York, United Kingdom Offers systematic reviews and health technology assessments Clinical Practice Guidelines support KSR Pain Evidence

26. Critical Appraisals (using ROBIS) and Evidence Summaries of all Systematic Review on Pain, including Cochrane Reviews, from 2010 (>2,500) Quick bottom-line Conclusions Assessments (using AGREE II) of relevant Clinical Practice Guidelines, from early 2016 RCT’s from 2010 KSR Pain Evidence

27. 100% unique content Extremely valuable content “State of the Union” on available evidence Used by Societies to write/update guidelines Used by insurance companies to determine policies on what treatment options to reimburse KSR Pain Evidence

31. Key User Benefits Very easy access to all critically appraised evidence in pain medicine: unique content nowhere else available Bottom-line conclusions inform users in one sentence about the potential clinical impact Users are informed about the reliability of the results reported in the studies Access to formally assessed Clinical Practice Guidelines

32. TARGET CUSTOMERS 1.Dubai Anaesthesia 2016 Conference: 3-5 March Mohammed Bin Rashid Academic Medical Center (http://dubaianaesthesia.com/) 2.National Pain / Anesthesiology Societies Emirates Anaesthesia & Pain Management Society (www.ema.ae) 3.Leading Pain Clinics HMC Qatar (https://www.hamad.qa/EN/news/2015/April/Pages/Hamad-Medical-Corporation%E2%80%99s- Anesthesia-Department-to-Open-More-Pain-Clinics-across-HMC-Hospitals.aspx) 4.Rehabilitation centers 5.Pharma / Corporate 6.Insurance companies 7.All Medical Schools & all hospitals Hospitals in UAE must have a Pain Committee for JCI accreditation

33. …helps build skills to recognize and understand the anatomical issues surrounding Child Maltreatment

34. Cases and images illustrate topics in Child Abuse, which are linked to relevant publications from the Child Abuse Evidence database, including 2,000+ full text review articles from The Quarterly Update Child Abuse Atlas

35. Examination Techniques / Technical Conduct Anatomical Map (external anogenital anatomy) Child Abuse Evidence database Evidence-based publications on Child Maltreatment, linked to relevant cases The Quarterly Update review journal Articles are linked to relevant cases SANE/SAFE Forensic Workbooks (online) Online & interactive by leading authors CE accreditation Case (peer) Review software Child Abuse Atlas – Learning Resources

36. 600+ Child & Adolescent Sexual Abuse Cases Including original cases from John McCann & David Kerns 150 different topics are covered > 1,500+ high resolution images Healing Visualization: video animations visualize the healing process Physical Abuse Cases are being added Sentinel/subtle injuries Strangulation Others topics to follow Create your own Cases / Case Reviews Create and upload your own cases and share them for case review purposes Document and store/archive your cases Child Abuse Atlas – Case Content

37. Child Abuse Atlas – Case Presentation

39. Child Abuse Atlas – link to evidence DB

40. TARGET CUSTOMERS 1.Children’s Hospitals Jalila Children's Hospital The Children's Medical Centre – Dubai Etc 2.Specialised Government Institutions CDA Dubai – Child Abuse Commission (Dr Shahraban Abdullah)  We can deliver a national Case Review platform for storing/archiving/sharing Cases. It can be used to request a second opinion or expert review 3.Medical School / University Hospital - Pediatric Departments Child Protective Services Child Abuse Pediatrics

41. Next Steps SELL!! SELL!! SELL!! SELL!!! SELL!! SELL!! SELL!! SELL!! SELL!!