1. Becoming a Leader in the Life Sciences 11/28/12 Reimbursement, Marketing, Sales & Distribution 1

2. Mike Clough - Background Education –B.A. Economics, St. Lawrence University –M.B.A. Marketing, S.U.N.Y. Buffalo Industry Experience –Eli Lilly and Company – Pharmaceutical Sales –Cordis, Johnson & Johnson – Neurosurgical Implants –Guidant – Coronary Stents –Edwards Lifesciences – Peripheral Stents –Endologix – Endovascular AAA Stent Grafts 2

3. Medical Device Companies An Insider’s Perspective Goals –Understand how/why medical device companies are created. –What background is ideal for each functional area of a MDC? – Is medical device industry a wise career choice in 2013? 3

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5. Education/background for MDC Sales Marketing R&D Regulatory Manufacturing Finance 5

6. Education/background for MDC - Sales 6

7. Education/background for MDC Marketing R&D Regulatory Manufacturing Finance 7

8. Medical Device Product Life Cycle 1. Dissatisfaction 2. Concept 3. Design 4. Raise $ 5. Product improvements 6. Regulatory 7. Manufacturing 8. Sales & Marketing 9. Commercialization 10. Acquisition 8

9. Dissatisfaction with Available Technology – Angio Catheters 9

10. Dissatisfaction with Available Technology – AAA Treatment 10

11. Dissatisfaction with Available Technology – AAA Treatment 11

12. Medical Device Product Life Cycle 1. Dissatisfaction 2. Concept 3. Design 4. Raise $ 5. Product improvements 6. Regulatory 7. Manufacturing 8. Sales & Marketing 9. Commercialization 10. Acquisition 12

13. Concept – Fenestrated Stent Graft 13

14. Medical Device Product Life Cycle 1. Dissatisfaction 2. Concept 3. Design 4. Raise $ 5. Product improvements 6. Regulatory 7. Manufacturing 8. Sales & Marketing 9. Commercialization 10. Acquisition 14

15. Product Life Cycle Example: Endologix Ted Dietrich, M.D. 2/11/02 Merger with Radiance Medical Systems 2005 FDA approval 4 generations in 6 years $0 - $100 million Ventana & Nellix Build value…takeover target 15

16. U.S. Medical Device Industry Geographic Concentration (Public Co’s) 16

17. Could Be Getting Worse… 17

18. Can Buffalo Challenge Minneapolis, Boston or Orange County, CA? U.B. Center of Excellence Roswell Park Cancer Institute Hauptman-Woodward Medical Research Institute Gates Vascular Institute U.B. Medical School Gates Vascular Institute Educated Work Force Low cost of living and wage scale Capital available 18

19. Future Favorable Demographics Impact of Changes to Health Care Delivery System 19

20. Favorable Demographics: Health Care Expenditures by Age 20

21. Impact of Patient Protection and Affordable Care Act (Obamacare) Undoubtedly: will slow the growth of health care spending. 21

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23. Impact of Changes to Health Care Delivery System (cont.) Slow growth rate in U.S. Market remains large OUS growth Still an industry with tremendous growth potential! 23