1. Psychology 355 15 - Drug Abuse

2. Psychology 3552 General Overview Problem of drug abuse Review of synaptic transmission Brain reward systems Mechanisms of tolerance and dependence

3. Psychology 3553 Drug abuse

4. Psychology 3554 Drug abuse Opioids and Morphine Derivatives Codeine Fentanyl Heroin Morphine Opium Stimulants Amphetamine Cocaine Ecstacy (MDMA) Methamphetamine Methylphenidate (Ritalin) Nicotine Other Compounds Anabolic Steriods Inhalants Cannabinoids Hashish Marijuana Depressants Barbiturates Benodiazepines Flunitrazepam (Rohypnol) Methaqualone (Quaaludes) Dissociative Anesthetics Ketamine PCP Hallucinogens LSD Mescaline Psilocybin http://www.nida.nih.gov

5. Psychology 3555 Drug abuse http://www.nida.nih.gov

6. Psychology 3556 Chemical synapses Basic Steps Neurotransmitter synthesis Load neurotransmitter into synaptic vesicles Vesicles fuse to presynaptic terminal Neurotransmitter spills into synaptic cleft Binds to postsynaptic receptors Biochemical/Electrical response elicited in postsynaptic cell Removal of neurotransmitter from synaptic cleft

7. Psychology 3557 Chemical synapses Neurotransmitters Amino acids: Small organic molecules e.g., Glutamate, Glycine, GABA Amines: Small organic molecules e.g., Dopamine, Acetylcholine, Histamine Peptides: Short amino acid chains (i.e. proteins) stored in and released from secretory granules e.g., Dynorphin, Enkephalins

8. Psychology 3558 Chemical synapses

9. Psychology 3559 Chemical synapses Receptors, agonists, & antagonists

10. Psychology 35510 Chemical synapses

11. Psychology 35511 Reinforcement

12. Psychology 35512 Reinforcement

13. Psychology 35513 Reinforcement

14. Psychology 35514 Reinforcement

15. Psychology 35515 Reinforcement

16. Psychology 35516 Tolerance and dependence

17. Psychology 35517 Tolerance and dependence

18. Psychology 35518 Tolerance and dependence

19. Psychology 35519 Tolerance and dependence

20. Psychology 35520

21. Psychology 35521

22. Psychology 35522

23. Psychology 35523

24. Psychology 35524

25. Psychology 35525

26. Psychology 35526

27. Psychology 35527

28. Psychology 35528

29. Psychology 35529

30. Psychology 35530