1. 1. How do you think the body repairs an injury, such as a cut on a finger? 2. How long do you think this repair process continues? 3. What do you think causes the cells to stop the repair process? Knowing When to Stop Suppose you had a paper cut on your finger. Although the cut may have bled and stung a little, after a few days, it will have disappeared, and your finger would be as good as new. The cut is repaired by the production of new cells through cell division. Cell division continues until the cut is repaired. Students will likely say that when the cut is filled in, there is no room for more cells to grow.

2. REGULATING the CELL CYCLE (8-3) http://www.travel-net.com/~andrews/images/animations/traffic.gif

3. Go to Section: Section Outline Regulating the Cell Cycle A.Controls on Cell Division B.Cell Cycle Regulators 1.Internal Regulators 2.External Regulators C.Uncontrolled Cell Growth Section 10-3

4. Go to Section: Control of Cell Division Section 10-3 Cells grow until they touch other cells If center cells are removed, cells near the space will start to grow again. SHOWS: Cell division genes can be turned on and off

5. CELL DIVISION GENES EXAMPLE: Cell division genes can be ________ in case of injury. Cells near injury are stimulated to divide to heal and replace damaged/missing cells and shut off when the repair has been made. turned on

6. CELL DIVISION GENES Some cells divide frequently (some human skin cells divide once/hour) Some cells divide occasionally (liver cells divide about once/year) Some cells don’t divide once they form (nerve cells)

7. In early 1980’s scientists discovered a protein in dividing cells that caused a ______________to form in _______________ cells CELL CYCLE REGULATORS Mitotic spindle NON-dividing Pearson Education Inc; Publishing as Pearson Prentice Hall

8. Levels of this protein rose and fell with the cell cycle so it was named __________ because it seemed to control the cell cycle. A whole family of CYCLINS have since been discovered that regulate the _____________________ in EUKARYOTIC CELLS CELL CYCLE REGULATORS CYCLIN TIMING of CELL CYCLE Pearson Education Inc; Publishing as Pearson Prentice Hall

9. ______________ REGULATORS Proteins that respond to events inside the cell. Allow cell cycle to proceed only if certain processes have happened EX: Cell can’t enter mitosis until all the chromosomes have been copied OTHER REGULATORS INTERNAL

10. ______________ REGULATORS Proteins that respond to events outside the cell. Signals tell cell to speed up or slow down the cell cycle EX: Growth factors stimulate cells to divide Especially important during wound healing and embryo development OTHER REGULATORS EXTERNAL http://www.suite101.com/files/topics/6234/files/tail_HumanTail.gif

11. Molecules on the surface of neighboring cells act as signals to slow down or stop the cell’s cycle. These signals prevent excessive growth and keep tissues from disrupting each other. EXTERNAL REGULATORS Pearson Education Inc; Publishing as Pearson Prentice Hall

12. Cancer cells have lost control of their cell division genes CHO (Chinese Hamster Ovary) cells in culture SEM Image by: Riedell

13. Cancer cells don’t stop when they touch nearby cells... they just keep growing! That’s what makes a tumor. NO CONTACT INHIBITION http://www.exn.ca/news/images/2000/08/02/20000802-cancer.jpg

14. Cancer cells Don’t stop dividing Like a “car with no brakes” Can spread to new places (METASTASIS) ______________ are substances that can damage DNA and cause cancer Ex: Cigarette smoke (OR CHEW), Radiation, chemicals in environment, even viruses, Carcinogens http://www.dfci.harvard.edu/abo/news/publications/pop/fall-winter-2004/images/metastasis_1.jpg

15. Cancer cells Cancer is complicated and can have many causes, but all cancers have one thing in common...… They have lost control over their _____________. Many cancers cells have a damaged or defective gene called _____, so they can’t respond to normal cell signals to control their growth. CELL CYCLE p53

16. ANTI-SMOKING commercial