1. What you need: Writing Utensil, Bellwork Sheet, Journal and virus worksheets. Bellwork Today: Draw and Label the viruses Have Homework out. (Journals and worksheet) Happy Wednesday, BIO-NINJAS

3. Vocab Quiz tomorrow over these words HOST CELL GENETIC MATERIAL VIRUSES RETROVIRUS IMMUNIZATION LYTIC LYSOGENIC HIV BACTERIOPHAGE CAPSID PATHOGEN PARASITE On your Vocab sheet: Highlight or mark these words then glue into your journal

4. You have 4 minutes to glue in your: Lysogenic Sheet and Lytic sheet. 4 minutes

5. Set up today’s page in your journal… Date: 2-3-15 Title: Viral Reproduction Essential Question: What takes place when a virus reproduces? YES - Cornell notes, please!

6. BIO.4C The student will: compare the structures of viruses to cells, describe viral reproduction describe the role of viruses in causing diseases such as human immunodeficiency virus (HIV) and influenza.

7. When a virus invades…

8. Viruses have both living and nonliving characteristics. LivingNon-Living Reproduce QuicklyNeed a host cell to function They have DNA/RNANot made of cells They can Mutate Do Not Grow/Develop Do not Metabolize/use energy Do not react to the environment

9. So…if viruses aren’t living, how do they reproduce?

10. 1. Lysogenic Cycle

11. Take a look at your “Lysogenic” sheet. Without me telling you anything, what do you think is happening in the diagram? *remember what you learned yesterday about virus structure

12. 1. Lysogenic Cycle Viruses “hide” for a while inside host cells before becoming active Example = HIV Steps to the Lysogenic Cycle: 1.Virus attaches to cell 2.Virus injects DNA/RNA 3.Virus DNA/RNA Integrates and Waits (months or years) in cell DNA 4.Virus DNA removes from cell DNA 5.Becomes active (starts lytic cycle) 6.Cell undergoes “lysis” (bursts)

13. Lysogenic Cycle - Viruses

14. Ways to remember… Lysogenic is a Looooooong word LYS-ogenic---> sounds like “lies” around or “lays low”

15. Lysogenic Example: HIV Enveloped virus Retroviruses transcribe RNA to DNA. Two viral strands of RNA found in core surrounded by protein capsid.

16. AIDS White blood count drops below 200 person is considered to have advanced HIV disease Most deaths occur with a white blood count less than 50 AZT = medicine used to treat HIV/AIDS – Blocks “reverse trascriptase”

17. Lytic Cycle

18. Take a look at your “Lytic” sheet. Without me telling you anything, what do you think is happening in the diagram? *remember what you just learned about virus replication

19. Lytic Cycle Lysis- to cut or to burst Active viruses enter cells and immediately begin to multiply, leading to the quick death of the invaded cells. Steps to the lytic cycle: 1.Attach to cell 2.Inject DNA/RNA 3.Produce (replicate) virus parts 4.Assemble new virons 5.Cell undergoes “Lysis”- viruses are released to infect other cells

20. Lytic Cycle - Viruses

21. Ways to remember Lytic = the shorter word, therefore shorter cycle Lytic = Bang Bang (kill you dead) Lytic  sounds like you got “lit up”

22. Lytic Example: Influenza Enveloped virus with a segmented RNA Symptoms appear within days/weeks Infects a wide range of animals other than humans Undergoes extensive mutations Causes the flu

23. Spread of influenza virus

24. Today’s Activity: Sage and Scribe

25. Happy Friday

26. Comic Strip

27. DISEASEVIRUSES AIDSHIV Wart Herpes Simplex Virus FluInfluenza MeaslesMorbillivirus. CancerHepatitis B Lytic or Lysogenic? Dengue Fever