1. Biozip Suture Group 24 Katie Good and Emily Schaefer Advisors: Bruce Beyer, M.D. Paul King, Ph.D.

2. Problem Statement Requirement Bioabsorbable zip-tie suture Performance Criteria Unidirectional Tension Maintain suture tied and tight Primary Objective Create suture allowing tactility and ease during deep tissue procedures

3. Quality Function Deployment

4. Current Technique Current sutures - application of tension in opposite directions Gynecological procedures - confined areas Difficult to apply tension Suture integrity compromised

5. Suture Tying http://www.brooksidepress.org/Products/Suturing_entrance.htm

6. Laparoscopic Technique Advantages Minimally invasive Requires tension in one direction Disadvantages More complex system Not widely used

7. Endoscopic Suturing System http://paresurgical.com/procedure.htm

8. Our Approach Require tension in one direction Noose type knot Shape memory Movie clip of a shape memory polymer (scroll to bottom) http://www.realknots.com/knots/noose.htm

9. Materials Monofilament vs. Braided Tensile Strength (0-gauge) Polyglactin 910 (Vicryl) ~ 95 N Polyglycolic Acid (Dexon) ~85 N Polyglyconate (Maxon) ~106 N Polydioxanone (PDS) ~82 N

10. Current Status Meeting with Dr. Beyer Monday 29 th to Discuss progress Ask surgery specific questions/concerns Continue literature search Meet with Dr. Shastri to discuss shape memory sutures

11. Future Work Select a material to optimize design Testing our designs in a virtual or real life simulator Find a manufacturer who produces material to get a quote for our design

12. References Bourne, R.B., MD, FRCSC, Bitar, H. MD, Andreae, P.R., BSC, Martin L.M., MB, BS, Finlay, J.B., PhD, & Marquis, F., MD FRCSC (1988). In-vivo comparison of four absorbable sutures: Vicryl, Dexon Plus, Maxon, and PDS. The Canadian Journal of Surgery, 31(1), 43-45. von Fraunhofer, J. A., Storey, R. S., Stone, I. K., & Masterson, B. J. (1985). Tensile strength of suture materials. Journal of Biomedical Materials Research, 19(5), 595-600.