1. Preliminary Results after Cataract Surgery with the Aspheric Acrysof ReSTOR IOL to Correct Presbyopia Meeting of the ASCRS Chicago 8-10 February 2007 R.M.M.A. Nuijts 1, N.E. De Vries, and J. De Brabander University Hospital Maastricht The Netherlands 1 Author receives travel expenses from ALCON

2. AcrySof ® ReSTOR ™ Model SN60D3 Apodized diffractive structure 3.6 mm center Refractive in periphery Incorporates +4.0 add at lens plane equaling +3.2 at spectacle plane 1.3 micron step larger steps: more light to near at center smaller steps: more light to distance at edge

3. AcrySof Aspheric IOL Design Posterior Aspheric Optic Symmetric Biconvex 6.0 mm Anterior Aspheric Optic Anterior Apodized Diffractive Optic Symmetric Biconvex 6.0 mm SN6AD3* SN60WF* The ReSTOR Aspheric IOL (SN6AD3) is designed with negative spherical aberration

4. Patients and Methods Prospective study aspheric ReSTOR –15 patients, 30 eyes with cataract –Bilateral implantation within 2 weeks –8-14 weeks follow-up –Mean age: 67 ± 8.0 years (range 52-81) Comparison with historical standard ReSTOR (SN60D3) group

5. Outcome Measures Patients were examined monocularly and binocularly ETDRS visual acuity charts logMAR visual acuity transferred to Snellen UCDVA and BCDVA Near visual acuity transformed into Snellen values Contrast sensitivity CSV-1000

6. Refractive Outcome Comparative data Standard ReSTOR (%) Aspheric ReSTOR (%) Number of eyes6530 Mean SE (D)0.06 ± 0.280.14 ± 0.49 SE ± 1.0 D (%)100 Mean Refractive Astigmatism (D) -0.78 ± 0.62-0.86 ± 0.60

7. Uncorrected Distance VA Aspheric vs Standard ReSTOR 0.5 0.63 0.8 1.0 1.25 0.79 0.89 0.68 0.85

8. Monocular Near VA Standard vs Aspheric ReSTOR

9. Aspheric vs. Standard ReSTOR IOL Monocular Mesopic Contrast Sensitivity Clinical Significance  0.3 log units at 2 or more Spatial Frequencies P=0.001 Vector Vision CSV-1000 P=0.04

10. Use of Spectacles Aspheric ReSTOR IOL Reading glasses: 0/15 Distance glasses: 0/15 –3/30 eyes scheduled for LASEK Computer glasses: 2/15

11. Adverse Effects 3/30 eyes scheduled for YAG capsulotomy 3/30 eyes scheduled for LASEK 1/30 re-operated for decentration 1/30 IOL exchange for postoperative ametropia No disturbing glare or halo’s

12. Conclusions Preliminary data of the aspheric ReSTOR IOL (SN6AD3): –Provides excellent near and distant VA –Mean monocular UCNVA: 0.96 –No glasses for near or distant vision 2/15 patients computer glasses –No disturbing glare or halos –Higher contrast sensitivity as compared to standard ReSTOR