Amino Acids and Proteins Amino Acids. L-isoleucine.

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Presentation transcript:

Amino Acids and Proteins Amino Acids

L-isoleucine

zwitterion

Synthesis of Amino Acids Strecker Synthesis

Gabriel Synthesis

Biosynthesis

Transamination

Polypeptides and Proteins

Carboxypeptidase

Trypsin, chymotrypsin

BrCN

Complete hydrolysis of a polypeptide gives: Gly, 3 Leu, 2 Tyr, 2 Phe, 2 Lys, Ser, 2 Met, Ala, Val, Ile, Arg, Pro Cyanogen bromide generates a tripeptide, a heptapeptide, and an octapeptide; each is sequenced: Leu-Pro-Phe Gly-Leu-Trr-Phe-Lys-Ser-Met Ala-Leu-Tyr-Lys-Val-Ile-Arg-Met

Partial hydrolysis with trypsin gives a tripeptide, a tetrapeptide, a pentapeptide, and a hexapeptide; each is sequenced: Val-Ile-Arg Met-Leu-Pro-Phe Gly-Leu-Tyr-Phe-Lys Ser-Met-Ala-Leu-Tyr-Lys What is the sequence for the original polypeptide?

Polypeptide and Protein Synthesis

Protecting Groups

Activating Groups

Automated Synthesis

Secondary Structures of Polypeptides and Proteins

Pleated Sheet

 -Helix

Tertiary Structures of Polypeptides and Proteins

Enzymes Carboxypeptidase A