Department of Medical Imaging

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Presentation transcript:

Department of Medical Imaging Noninvasive Measuring Brain pH and Biomarker of Brain Tissue Using MR Technology Ren-Hua Wu, Dr. med. Department of Medical Imaging Shantou University China

Background Our ongoing studies

Background: Normal or Abnormal? T1WI T2WI MRS

T1WI T2WI DWI 5h after ictus ADC MRS

Glioma or acoustic neuroma? Pilocytic astrocytoma

Differential diagnosis Biopsy CT, MR, PET/CT Contrast media

1H谱 1H MRS

31P MRS

MRS Multi-voxel Single voxel

Background Data from Louis N. Manganas, et al. Science 318, 980 (2007) Identify Neural Progenitor Cells Data from Louis N. Manganas, et al. Science 318, 980 (2007)

Detecting cell apoptosis by MRS Control Cell apoptosis Cao Z, et al. World J Gastroenterol. 2008;14(24):3891-6

Non-invasive detection of hippocampal sclerosis Data from Hammen T, et al. NMR Biomed. 2008 Jul;21(6):545-52 .

Background：Benign or Malignant？ ET/CT

Background-pH imaging Gallagher FA, et al. Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate. Nature. 2008;453(7197):940-3.

Background: 1H pH imaging Data from Zhou JY, et al. Nature Medicine. 2003; 9(8):1086-1090.

Background: 31P pH imaging Wu RH, et al. Chwee Teck Lim, James C.H. Goh (Eds.): ICBME 2008, Proceedings 23, pp. 362-365, 2009

Our ongoing studies 1.28 ppm biomarker is dominant in mesenchymal stem cells and adipogenic differentiation induced. 1.28 ppm signals is not specific for Neural Progenitor Cells

Mesenchymal stem cell before and after differentiation

B-1 A B-2 B Fig.B.The spectra of control group (A) and model group (B). The spectra of glutamate at 2.35 ppm is lower than control group. model for Alzheimer's disease

control 60 days 70 days

A：Mouse brain B：Human glioma C：human esophagus carcinoma D： Mesenchymal stem cell

Our ongoing studies：pH imaging in model FSE sequence

Our ongoing studies：pH imaging in model

pH Imaging T2WI pH-sensitive imaging pH-sensitive imaging with color

pH sensitive imaging: GRE-MT -200 Before editing After editing

Acknowledgements National Natural Science Foundation of China (NSFC) Li Ka Shing Foundation

Acknowledgements