Top 10 Enemies of Spider-man

#10 Sandman With the FBI and police on his tail, Marko traveled to a refuge in a place where he was unlikely to be found: an atomic testing site near Savannah, Georgia. As he rested on a nearby beach, the experimental reactor's steam system exploded, bombarding him with a massive dose of radiation and apparently bonding his body with the sand. The Sandman embarked on a criminal career that led him into conflict with Spider-Man, the Fantastic Four, Hulk, and many other heroes. After failing to defeat Spider-Man as a member of the Sinister Six under Doctor Octopus, he joined forces with the Wizard.

#9 The Rhino Seduced by promises of wealth and power, Aleksei underwent a life-threatening series of chemical and radiation treatments to transform him after several months into the superhumanly strong agent for a collective of professional spies - in part, to support his family. As the Rhino made his way towards New York City, Spider-Man began to formulate how to defeat this apparently unstoppable foe. His discovered two key factors: once charging, the Rhino cannot change directions or easily halt his advance. Second, Aleksei is rather dumb.

#8 The Lizard From his home in the Everglades, Dr. Connor’s made a serum taken from the DNA of a reptile. He had successfully regrown the missing limb of a rabbit and chose to test it on himself. Connors ingested it, and his arm did indeed grow back. Unfortunately, it had one side effect: Connors was subsequently transformed into a reptilian monster! Spider-Man learned about this and travelled to Florida, helping the doctor by using Connors' notes to invent a serum to cure him.

#7 Kraven the Hunter Kraven used a mystical serum to give him similar strength to Spider-Man, but even without the serum he was a threat to the wall- crawler. However, Kraven's continual underestimation of the superhero's resourcefulness made him a frustrating quarry.

#6 Electro At the beginning of Electro's criminal career, J. Jonah Jameson began a smear campaign in the Daily Bugle proclaiming Electro to actually be an alter-ego for Spider-man. Intent on proving the publisher wrong, Spider-man faced Electro and was nearly killed by merely touching him. Using a fire hose, however, the web-slinger was able to defeat Electro. Sometime later in another attempt to deface Spider-man's reputation, Jameson secured Electro's supercharged services to battle the web-slinger on national television. Before an audience of millions, Spider-Man stood triumphant once more. Dillon was humiliated.

#5 Carnage The Carnage symbiote has occasionally attached itself to other hosts, including the Silver Surfer, Ben Reilly (a clone of Spider-man), and Doctor Octopus. Venom later decided to absorb the Carnage symbiote "for good", during which Kasady retained the Carnage persona by costuming himself in red paint and continuing his killing sprees. This was short lived, however, as Kasady coincidentally found an exact replica of the symbiote in the Negative Zone. As to whether or not the symbiote is a separate entity, "permanently" bonded, or his own blood mutated, has not been revealed. The symbiote once chose to leave Kasady and bond with Ben Reilly. More on Marvel.com:

#4 Venom Brock had been a successful columnist for the newly revived Daily Globe until he began writing a series of articles about the “Sin-Eater murderers”. A bogus offender had confessed to Brock about committing the murders. While protecting the "murderer's" identity under the First Amendment, Brock wrote a series of stories in the Globe detailing his dialogue with the supposed killer, until mounting pressure from the authorities forced him to write an exclusive revealing the murderer's name. Although that edition of the paper sold out immediately, Spider-Man soon revealed the true identity of the Sin-Eater to be Detective Stan Carter, making Brock a laughingstock among his fellow journalists. Fired from the Daily Globe, he was forced to write venomous drivel for scandal newspapers. Brock's wife left him, and his future appeared to be over. Brock blamed his predicament on Spider-Man.

#3 The Hobgoblin Using information he acquired from journals left behind by Norman Osborn, Kingsley intended to blackmail several key figures including J. Jonah Jameson and Osborn's son Harry. Inevitably, this drew him into conflict with Spider-man, who Kingsley saw as only a nuisance and had only planned to deal with him in afterthought. After being beaten soundly by the web-slinger several times, Kingsley became obsessed with reproducing Osborn's original strength enhancing formula so he could deal with Spider-Man more effectively. Not wanting to suffer the insanity that plagued Norman Osborn as a result of exposure to formula, Kingsley decided to test it on a small time thug named Arnold “ Lefty” Donovan. After exposing him to the formula, Kingsley had Donovan attack Spider- Man in the guise of the Hobgoblin. Kingsley monitored Donovan's vitals from afar, checking for anomalies. Spider-man defeated Donovan and unmasked him, but before he could compromise Kingsley's identity, he remote-controlled the goblin glider to crash, killing him.

#2 Doc Ock During an accidental radiation leak that ended in an explosion, the apparatus became fused to Octavius' body. It was later revealed that the radiation,had mutated his brain so that he could control the movement of the arms using his thoughts alone. The tentacles have since been surgically removed from his body, although Octavius retains the power to control them telepathically from a great distance. The accident also seemingly damaged his brain (although it was later suggested that what was interpreted as brain damage was in fact his mind rewiring itself to accommodate four extra limbs), and the scientist turned to a life of crime.

#1 The Green Goblin The Green Goblin, also known as Norman Osborn, tested a serum upon himself in his private lab, but the unstable concoction exploded in his face leaving him hospitalized for weeks. He emerged smarter and superhumanly strong, but at the cost of his sanity. After having battled spider-man several times and losing to him the Green Goblin decided to make things personal by attacking Mary Jane Watson who was Peter Parker’s girlfriend. By attacking Mary Jane he earned a battle with Spider-man. While in battle, a building collapsed and Mary Jane was teleported to another demention by a device the Green Goblin sought, called Time- Dilation Accelerator. With that happening it made Spider-man think that Spider-man was dead, which drove Spider-man into a great fury.