Storage capacity: consider the neocortex ~2010^9 cells, 2010^13 synapses.

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Presentation transcript:

Storage capacity: consider the neocortex ~20*10^9 cells, 20*10^13 synapses

Hebb’s postulate “When an axon of cell A is near enough to excite cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that A’s efficiency, as one of the cells firing B, is increased.” From the “Organization of Behavior” by D. O. Hebb (1949) Cells that fire toghether are wired together

Stent’s postulate “ When an axon of cell A repeatedly and persistently fails to excite the postsynaptic cell B while cell B is firing under the influence of other presynaptic axons, metabolic change takes place in one or both cells such that A’s efficiency, as one of the cells firing B, is decreased.” Cells that fire out of sinc lose their link

NMDA receptor is the “coincidence detector”

Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. By Shi et al. (1999) Science 284: