Test 1Test 2Test 3Test 4Test 5Test 6 Sensitivity2.510.576.1608887.2 Specificity100 917098.296.3 PPV100 90.574.598.397.3 NPV475376.562.587.586.5 Performance.

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Presentation transcript:

Test 1Test 2Test 3Test 4Test 5Test 6 Sensitivity Specificity PPV NPV Performance Characteristics of Six Commercial IgM Tests Relative to the CDC IgM Capture EIA* * Assay comparison study was an ARRA-funded project done in conjunction with the APHL Santa Clara County Public Health Department and Iowa State Hygienic Laboratory performed the testing.

Measles Specimens Referred to CDC for Confirmatory or Reference Testing – 2006 to 2011

National Center for Immunization and Respiratory Diseases Division of Viral Diseases Measles was laboratory-confirmed in 48 (87%) cases 20 (42%) by detection of measles-specific IgM antibodies only 24 (50%) by detection of measles-specific IgM antibodies and measles virus RNA 4 (8%) by detection of measles virus RNA only Laboratory Confirmed Measles Cases in USA: 2012

National Center for Immunization and Respiratory Diseases Division of Viral Diseases Laboratory Confirmed Measles Cases in the USA, 2013 with Laboratory Results Shared with CDC IgM only32 (45%) IgM and PCR26 (37%) PCR only12 (17%) Total70

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