Consensus procedure for the management of children with ESRD
Questions/aims Aim Defining consensus-based benchmarks 1.Do we agree with the current guidelines for the management of ESRD in children? 2.Are there any gaps? 3.What needs to be improved?
Questions: Do we/you know the guideline? Do we/you agree with it? What are the limitations? Do we/you use it? If so, is this visible in the results? What needs to be improved?
Indicators -Hemoglobin -Blood pressure -Phosphate -PTH (target) -Calcium -CaXP -Dyslipidemia Benchmark
Hemoglobin Lower treshold: 2 yr: 11 g/dl or 6.8 mmol/l Upper threshold: normal value for age Target: 70%
Hb Hb too high Anemia 15% 46% 40% 8% 12% 41% 47% 50% 38% 12% 44% 52% 4%
Best practice i 52% 35% 13% M0 N=31 M12 N=14 7% 71% 22% M24 N= 6 83% Hb too high Anemia
Blood Pressure ( diastolic and systolic) < p95 for age, gender and height According to the Task Force Report 2004 Target: 75%
Blood pressure > p95 38% 33% 24% 17% 38% 62% 38% 65% 35% 25% 19% 22% 75% 81% 78%
Best Practice Systolic Diastolic 29% 71% 38% 62% 100% 17% 83% 100% M0M12M24 N=24 N=8 N=6 M0M12M24 N=24 N=8 N=6 BP> p95
Phosphate normal values for age (ESPN) Based on: ESPN 0-1 yr: mmol/l ( mg/dl) 1-4 yr: mmol/l ( mg/dl) 5-11yr: mmol/l ( mg/dl) 11yr: mmol/l ( mg/dl) Target: 60%
Phosphate 40% 36% 25% 30% Too high Too low Age corrected Too high Too low according to ESPN 39% 53% 8% 38% 55% 7% 48% 39% 13%
Best Practice phosphate 32% 58% 10% 43% 57% 83% 17% M0 N=31 M12 N=14 M24 N=6 Too high Too low according to ESPN
Indicators -PTH Target -CalciumBenchmarks -Dyslipidemia
Proposal iPTH ? pg/mL Based on:Evidence: 1.KDOQI >145 pg/ml (>16 pmol/l) <300 pg/mL (<33 pmol/l) Adults: C Children: C
iPTH 24% 52% 33% 42% 43% Too high Too low According to KDOQI 24% 25% 14%
Best Practice (iPTH) Too high Too low 37% 56% 7% 43% 14% 25% 50% 25% M0 M12 M24 N=30 N= 14 N=4
Target???
Proposal Calcium ? mg/dL Based on:Evidence: 1.KDOQI mg/dl (mmol/l) 0-5 mo 8,7 -11,3 (2,18-2,83) 6-12mo 8,7- 11,0 (2,18-2,75) 1-5 y 9,4 -10,8 (2,35-2,70) 6-12 y 9,4- 10,3 (2,35-2,58) 13-20y 8,8 –10,2 (2,20-2,55) Adults: D Children: D 2. ESPN mg/dl (mmol/l) “ child”: ( ) “thereafter”: ( ) Children: D
Calcium (ESPN) 12% 11% Too high Too low According to ESPN 10% 14% 19% 1% 4% 76% 80% 77%
Best practice 30% 70% 100% N=10 N=4 Too high Too low According to ESPN
Proposal CaXP ? mg/dL Based on:Evidence: 1.KDOQI <12yr:CaXP<65 mg 2 /dL 2 (5.2 mmol 2 /l 2 ) >12yr:CaXP<55 mg 2 /dL 2 (4.4 mmol 2 /l 2 ) Adults: C Children: D 2. ESPN CaXP < 60 mg 2 /dL 2 (4.8mmol 2 /l 2 ) Children: D 3. NfN CaXP<55 mg 2 /dL 2 ( 4.4 mmol 2 /l 2 )
Proposal all lipids Based on:Evidence: 1.KDOQI Normal values (for age and gender) Adults: D Children: D 2. ESPN Only normal values for total cholesterol and triglycerides (for age and gender) None - Cholesterol ( Total, LDL, HDL) - Triglycerides
Total cholesterol 24% 13% 17% ) Too high According to ESPN
LDL cholesterol 22% 16% 19% Too high> 110 mg/dl
HDL cholesterol 24% 35% 39% Too low< 35 mg/dl
Triglycerides (not after fasting!) 60% 75% 61% ESPN handbook 2002, after 12 h fasting! Age and gender corrected
Questions/remarks?
Proposal CRP< ? Mg/L Based on:Evidence: 1.KDOQIAdults: D Children: D