Albuterol’s Effect on the β2-Adrenergic Receptor

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Albuterol’s Effect on the β2-Adrenergic Receptor Enna van den Akker

Albuterol Intro One in twelve Americans suffer from asthma 3.7% of Americans diagnosed with Bronchitis in the past year. Used to increase lung function Medicine for asthma and bronchitis Ligand for a β2-adrenergic Receptor Results in smooth muscle relaxation and bronchodilation

With Albuterol Albuterol G-Protein β2-Adrenergic Receptor Adenylyl Cyclase GDP cAMP Ca2+ ATP GTP Protein Kinase A Myosin Light chain Phosphatase Ca2+ Ca2+ Myosin Light chain Kinase K P Calcium Channel Calcium Activated Potassium Channel

Without Albuterol G-Protein β2-Adrenergic Receptor Adenylyl Cyclase GDP cAMP Ca2+ ATP GTP Protein Kinase A Myosin Light chain Phosphatase Ca2+ Ca2+ Myosin Light chain Kinase K Calcium Channel Calcium Activated Potassium Channel

Conclusion Causes of bronchodilation and smooth muscle relaxation Decreased cellular concentration of calcium Opening of potassium channels Inactivation of myosin light chain kinase

Works cited Images adapted from: https://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwjSq_yxjZ7JAhVDTCYKHVtTDlMQjRwIBw&url=http%3A%2F%2Fwww.uspbp ep.com%2Fusp31%2Fv31261%2Fusp31nf26s1_alpha-19-31.asp&psig=AFQjCNEQYEhNWbogI2WgtyP5VAhWpIlzGg&ust=1448078057741858

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