Towards an HIV Cure: Canadian Global Stakeholder’s Engagement Workshop 21 July 2015, 18h30 – 20h30 The International AIDS Society (IAS) Towards an HIV Cure initiative, together with our Canadian partners CANFAR, CIHR, CanCURE and CATIE aim to encourage community contribution from the diverse Canadian populations invested in HIV cure research. In partnership with:Sponsored by:

Towards an HIV Cure: Canadian Global Stakeholder’s Engagement Workshop Vancouver Overview of the IAS Towards an HIV Cure Initiative: Community Efforts and Looking Towards 2016

Towards an HIV Cure: Mission  Facilitate scientific discussion, exchange and collaboration to promote and accelerate research towards a cure for HIV  Provide leadership in advocating for increased investment and resource optimization in HIV cure research  Provide clear and accurate information and disseminate knowledge to the broader community

Initiative Organisation Advisory Board Industry Collaboration Group Cost-effectiveness Working Group Psychosocial Studies Working Group International Scientific Working Group Ethics now integrated throughout the entire initiative

Advisory Board

Scientific Discussion, Exchange & Collaboration  Facilitate scientific discussion, exchange and collaboration to promote and accelerate research towards a cure for HIV

Global Scientific Strategy The International AIDS Society scientific working group on HIV Cure. Towards an HIV cure: a global scientific strategy. Nature Rev. Immunol. 18 Jul 2012 (doi: /nri.3262)

Global Scientific Strategy 2016 Formation of International Scientific Working Group: Steering Committee: Jintanat Ananworanich, US Military HIV Research Program Françoise Barré-Sinoussi, Institut Pasteur / Inserm Monsef Benkirane, Institute of Human Genetics, CNRS Steven Deeks, UCSF Sharon Lewin, The Doherty Institute Anna Laura Ross, ANRS / IAS Joseph Tucker, UNC China Project

Global Scientific Strategy 2016 Identification of sub-groups 1.Molecular biology of HIV latency and shock strategies; Chairs: Monsef Benkirane & David Margolis 2.Viral reservoirs, immunology of HIV persistence and kill strategies; Chairs: Steven Deeks & Daniel Douek 3.Models for HIV cure or sustainable remission; Chairs: Jintanat Ananworanich & Jeffrey Lifson 4.Gene/cell therapy; Chairs: Paula Cannon & Daniel Kuritzkes 5.Novel biomarkers and technologies to analyse/quantify HIV reservoirs; Chairs: Sharon Lewin & John Mellors 6.Social sciences and health system preparedness. Chairs: Joseph Tucker & Ying-Ru Lo

Global Scientific Strategy 2016 TimelineAction point February – June 2015Circulation of subgroup draft documents, coordinate development within sub-groups 22 June 2015Submit developed text per sub-group to IAS 20 July nd plenary meeting of ISWG July – October 2015First draft of the Global Scientific Strategy November 2015 – January 2016 Peer review process of the Global Scientific Strategy Q1, 2016Pre-final version of Global Scientific Strategy February rd plenary meeting of ISWG March/April 2016Preparation of publication July 2016Aim to have article published and launch of the Global Scientific Strategy in Durban (full recommendations prepared and final)

Working Group activities Industry Collaboration Group Enhance dialogue and interaction between public and private sectors Common MTA for the use of ARVs in pre-clinical studies Diagnostic companies; Therapeutic vaccination/immune modulation; Eradicare database. Cost-effectiveness and Public Health Working Group Opinion piece on the role of mathematical modeling and cost- effectiveness analysis in the HIV cure research agenda. Psychosocial Studies Group Joined forces with the Cost-Effectiveness and Public Health WG to write a multi-disciplinary scientific agenda for HIV cure research article.

Towards an HIV Cure Symposium 2010: HIV Reservoirs Workshop, Vienna 2012: HIV Cure Symposium, Washington DC 2013: HIV Cure Symposium, Kuala Lumpur 2014: HIV Cure Symposium, Melbourne, Australia 2015: HIV Cure Symposium, 18 th -19 th July, Vancouver, Canada

Investment in HIV cure research  Provide leadership in advocating for increased investment and resource optimization in HIV cure research

Evaluating and monitoring Investment  Resource Tracking Survey of global investment in HIV cure research and development in 2012, 2013 and 2014 In collaboration with

Knowledge dissemination and information sharing  Provide clear and accurate information and disseminate knowledge to the broader community

Knowledge dissemination and information sharing

Community Engagement  Community Scholarships for the annual Towards an HIV Cure Symposium  Call for Nominations for Community Representatives to ensure fair representation in working groups and throughout the initiative  HIV cure fact-sheet developed in collaboration with community members  Community engagement and training workshops (Washington DC, Chennai, Melbourne, Vancouver…) We want to hear your ideas and suggestions!

Acknowledgements  Sponsored by:  In Partnership with:

Acknowledgements  Towards an HIV Cure Initiative Sponsors: