Joshi et al., 2013 Glutamate Activity in ACC Statistical Significance: **p≤0.01 Spectroscopy in Adolescent Males with HF-Autistic Disorder Higher glutamate.

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Joshi et al., 2013 Glutamate Activity in ACC Statistical Significance: **p≤0.01 Spectroscopy in Adolescent Males with HF-Autistic Disorder Higher glutamate in this area of the brain is hypothesized to be associated with ASD.

Clinical Trials ClinicalTrials.gov Registration Number: NCT URL: Study Approved by: Partners Human Research Committee Institutional Review Board Study Funded by: the Norma Fine Pediatric Psychopharmacology Fellowship Fund & the Pediatric Psychopharmacology Council Fund 12-week Open-label Trial of Anti-Glutamate Agent Memantine Hydrochloride (Namenda) for the Treatment of Social Impairment in Young Adults with High-functioning Autism Spectrum Disorder Clinical and Research Program in Pediatric Psychopharmacology

ASD Features: Mean Response Informant-Rated: Social Responsiveness Scale (SRS) Clinical and Research Program in Pediatric Psychopharmacology SRS:Mean Raw Score Baseline:99 ±17 Endpoint:71 ±18 Reduction:28 ±25 Effect Size:1.57 Statistical Significance: *p≤0.05, **p≤0.01, ***p≤0.001 *** Take away: Caretakers rated patients to have improvements in social skills and behavior after trial of Namenda.

Total Mean Response *** Mean Response by Domain ASD-RSMean Total Baseline:31 ±7.4 Endpoint:21 ±8.3 Reduction:10 ±7 Effect Size:1.30 Clinical and Research Program in Pediatric Psychopharmacology Clinician-Rated: ASD Rating Scale ASD Features: Mean Response Statistical Significance: *p≤0.05, **p≤0.01, ***p≤0.001

Non-verbal Communication Performance Clinical and Research Program in Pediatric Psychopharmacology Reading Non-Verbal Emotional Cues: DANVA2 Performance Total Errors Statistical Significance: *p≤0.05, **p≤0.01, ***p≤0.001 Take Away: After medication, patients show increase in abiity to recognize emotions conveyed through facial expressions

Adverse Events Clinical and Research Program in Pediatric Psychopharmacology Reported > I visit Experienced any AEs: 6 (33.3%) Serious AEs: None Treatment Limiting AEs: N=1 Decreased energy, emotional numbness, feeling dissociated, feeling on edge (resolved on d/c) Take away: Patients reported very few adverse side effects while on Namenda

Reimer, Fried, Biederman et al., 2013 Impaired driving ability associated with autism The MIT AgeLab Driving Simulator Characterizing Driving Behavior in Young Adults with ASD Difficulties attending to the roadway: - Higher vertical gaze position - Wider dispersion of horizontal gaze scanning - Focus more on the median Drive at higher level of arousal: - Increased level of anxiety