Melatonin Plays a Role as a Mediator of Nocturnal Pain in Patients with Shoulder Disorders by Eunyoung Ha, Yun-Mee Lho, Hyuk-Jun Seo, and Chul-Hyun Cho.

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Presentation transcript:

Melatonin Plays a Role as a Mediator of Nocturnal Pain in Patients with Shoulder Disorders by Eunyoung Ha, Yun-Mee Lho, Hyuk-Jun Seo, and Chul-Hyun Cho J Bone Joint Surg Am Volume 96(13):e108 July 2, 2014 ©2014 by The Journal of Bone and Joint Surgery, Inc.

The mRNA expression of MTNR1A, MTNR1B, and ASIC3 was increased in both the rotator cuff tear (RCT) and frozen shoulder (FS) groups in comparison with the control (CTL) group of patients with shoulder instability. Eunyoung Ha et al. J Bone Joint Surg Am 2014;96:e108 ©2014 by The Journal of Bone and Joint Surgery, Inc.

The effect of proinflammatory cytokines on the expression of MTNR1A and MTNR1B was determined with use of primary cultured fibroblast-like synoviocytes. Eunyoung Ha et al. J Bone Joint Surg Am 2014;96:e108 ©2014 by The Journal of Bone and Joint Surgery, Inc.

Melatonin increased the expression and level of ASIC3. Eunyoung Ha et al. J Bone Joint Surg Am 2014;96:e108 ©2014 by The Journal of Bone and Joint Surgery, Inc.

Melatonin increased IL-6 production. Eunyoung Ha et al. J Bone Joint Surg Am 2014;96:e108 ©2014 by The Journal of Bone and Joint Surgery, Inc.

Luzindole reversed melatonin-stimulated expression and level of ASIC3. Eunyoung Ha et al. J Bone Joint Surg Am 2014;96:e108 ©2014 by The Journal of Bone and Joint Surgery, Inc.

Luzindole reversed melatonin-stimulated IL-6 production. Eunyoung Ha et al. J Bone Joint Surg Am 2014;96:e108 ©2014 by The Journal of Bone and Joint Surgery, Inc.