بسم الله الرحمن الرحيم

Clinical Pharmacy in Pediatric Nephrology Ihab El-Hakim

Clinical Pharmacy Is the branch of pharmacy in which pharmacists provide patient care that optimizes medication therapy and promotes health, wellness, and disease prevention. Its practice is centered inside the hospitals and clinics in company with physicians for the purpose of ensuring optimal medications’ prescription. A clinical pharmacist should have a foundational understanding of the biomedical, pharmaceutical, socio- behavioral, and clinical sciences (American College of Clinical Pharmacy,

Pediatric Nephrology Functional anatomy of the kidney Physiological roles of the kidney and UT Drug handling by the kidney Clinical conditions (presentations, investigations, therapy) –Glomerular: AGN, MLNS –Tubular: deToni-Debré-Fanconi syndrome –Hypertension –UTI Chronic renal failure, drugs in CRF Dialysis, drugs and dialysis Transplantation

Functional anatomy of the kidney

Functional anatomy of the UT

Physiology 1.3 million nephrons in each kidney The total area of the glomerular capillary endothelium across which filtration occurs is about 0.8 m 2. The filtration slits are approximately 25 nm wide and each is closed by a thin membrane. They permit passage of neutral substances up to 4 nm diameter and almost totally exclude substances with 8 nm or greater diameter. Also charges on the molecules affect their passage.

Physiology Glomerular function FILTRATION –Renal blood flow (RBF) about 25% of cardiac output. More in cortex than medulla. –Glomerular capillary pressure 40% of systemic arterial pressure. –Various substances affect the afferent or efferent arterioles differently hence the net effect on glomerular filtration pressure varies. –Clearance of a substance: is the volume of plasma cleared from that substance per minute. Most commonly used is creatinine. Clearance = (U cr x V)/(P cr ) (mg/ml x ml/min)/(mg/ml)

Physiology Tubular functions REABSORPTION and SECRETION

Physiology

Bladder function STORAGE and MICTURITION

Drug handling by the kidney Kidneys are involved in the process of elimination of drugs. Drugs may be filtered, reabsorbed or secreted by glomeruli and tubules in an active or inactive form. Filtrtation is passive and nonsaturable. Protein-bound drugs are poorly filtered. Weak acid drugs are secreted in PCT. Lipid soluble drugs are rapidly reabsorbed. Some drugs may be metabolized in the kidney.

Some Clinical Conditions Commonest cause is post streptococcal Triad of oliguria, gross hematuria and hypertension. In some cases there may be proteinuria or renal impairment. Investigations: urine analysis, renal functions, ASOT, serum electrolytes, serum C3. Therapy includes fluid and salt restriction, antihypertensive drugs, antistreptococcal antibiotics. In rare conditions dialysis may be required. Glomerular diseases Acute glomerulonephritis

Some Clinical Conditions Age 2-8 years Albuminuria, hypoalbuminemia, hypercholoesterolemia, generalized edema. In some cases there may be hematuria, hypertension or renal impairment. Investigations: urine analysis, renal functions, serum lipids and proteins, CBC. Therapy includes ample fluid intake, high protein diet, diuretics and albumin transfusion are controversial, corticosteroids in max dose except in presence of hypertension or infection Glomerular diseases Minimal lesion nephrotic syndrome

Some Clinical Conditions Generalized proximal renal tubular dysfunction with impaired reabsorption of aa, bicarbonate, glucose, P, urate, Na, K, Mg, Ca and low molecualr weight proteins Either priamary or secondary. Polyuria, dehydration, metabolic acidosis and glucosuria. Growth retardation and rickets Investigations: urine analysis, serum electrolytes, ABG. Therapy includes replacement of all substances lost in urine to keep their serum levels within normal. Tubular diseases De Toni-Debré-Fanconi syndrome

Some Clinical Conditions Systemic hypertension

Some Clinical Conditions Systemic hypertension Non-pharmacological treatment Pharmacological treatment Investigations, prevention and treatment of complications

Some Clinical Conditions Urinary tract infection May be lower or upper UTI Symptoms of lower UTI include dysuria, frequency, hematuria, suprapubic pain. Upper UTI presents with fever, loin pain. Investigations: urine analysis, culture and antibiotic sensitivity, CBC. Recurrence warrants investigation for predisposing factors.

Chronic Renal Failure Progressive and usually irreversible loss of renal function. GFR <= 60 ml/min/1.73m 2 End stage renal disease (ESRD) ehen life cannot be maintained without renal replacement therapy (dialysis or transplantation). GFR<10-15 ml/min/1.73m 2 Clinical symptoms: –Oligo-polyhydramnios –Failure to thrive –Anorexia, nausea, vomiting, fatigue –Pruritis –Oliguria, polyuria –Delayed puberty –Pallor –Bone deformities –Hypertension –Edema

Chronic Renal Failure Metabolic abnormalities – Hyponatremia – Hyperkalemia – Metabolic acidosis – Hyperuricemia – Hypocalcemia – Hyperphosphatemia Renal osteodystrophy – Hypovitaminosis D – Hyperparathyroidism Anemia Growth failure Delayed puberty Cardiovascular disease GI bleeding Platelet dysfunction Treat hypertension Reduce proteinuria Correct anemia Reduce salt and fluid intake Control hyperlipidemia Control hyperphosphatemia Control hyperkalemia Treat renal osteodystrophy Revise drugs and their doses

Dialysis Principle Indications –Clinical manifestations (encephalopathy, pericarditis) –Metabolic problems not responding to medical treatment –Fluid overload –Rapid rise in parameters of renal function. Modalities –Peritoneal dialysis (PD) –Hemodialysis (HD)

Dialysis

PDHD

Drugs in Chronic Renal Failure and Dialysis

Renal Transplantation Team Donor Recipient Preparation Procedure Protocol Follow up Complications Rejection