Cancer Historically agents given systemically – Agents that kill rapidly dividing cells Find therapeutic dose  Kills tumor cells w/o killing patient –

Slides:

Advertisements

Similar presentations

Mechanical and Industrial Engineering University of Massachusetts Amherst, MA, USA Nanomedicine Jonathan P. Rothstein.

Advertisements

Mechanical and Industrial Engineering University of Massachusetts Amherst, MA, USA Nanomedicine Jonathan P. Rothstein.

Mechanical and Industrial Engineering University of Massachusetts Amherst, MA, USA Nanomedicine Jonathan P. Rothstein.

Cell membranes are composed of two phospholipid layers.

 Since the cell cycle is known, now we must ask what controls it  Noted that healthy cells in contact will not divide ◦ Essentially, this is how our.

CHAPTER 10 Basic Biopharmaceutics

Cell Transport The movement of molecules can be either passive (no energy) or active (needs energy) depending upon the membrane structure and concentration.

Cancer Imaging Topics in Bioengineering. The present and future role of cancer imaging Fass L. (2008) Mol Oncol. Figures 1 & 2.

Nanomedicines for diagnosis and therapy. Nanomedicines.

Dental Microbiology #211 IMMUNOLOGY 2006 Lecture 2 The Lymphocytes.

Delivery Of Proteins: Target Site-specific Delivery By The Parenteral Route Saeb Aliwaini1.

Nanotechnology and medicine Dina Khater – 3 April SFC.

 Since the cell cycle is known, now we must ask what controls it  Noted that healthy cells in contact will not divide ◦ Essentially, this is how our.

Diabetes: Glucose Monitoring

Mosby items and derived items © 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Chapter 2 Drug Action and Handling.

 Cell cycle is known, so now we ask what controls it  We have observed many factors that influence a cell’s ability to move forward in the cycle ◦ Kinetochores.

.  Based on particle size and surface charge characterization studies, both nanoparticles have successfully been synthesized.  Successful conjugation.

Keith Johnston Research Group Nanotechnology/Colloid Science CPE Biomedical and Pharmaceutical.

Antibody and prodrug therapy of cancer

SCALABLE PRODUCTION OF POLYMERIC NANOPARTICLES YING LIU ASSISTANT PROFESSOR DEPARTMENT OF CHEMICAL ENGINEERING DEPARTMENT OF BIOPHARMACEUTICAL SCIENCES.

Mitosis & Cancer: When Making New Cells Goes Terribly Wrong.

Dr. Liviu Movileanu Associate Professor Department of Physics and Structural Biology Syracuse University USA Editorial Board Member.

Fighting Cancer with Gold Nanoshells.

18 Animal Defense Systems Animal defense systems are based on the distinction between self and nonself. There are two general types of defense mechanisms:

Nanodiamond Drug Delivery Austin Ramos Biomedical Engineering, URI BME 281.

 Nanotechnology is the study of particles 1x10 ^-9 of a meter in size.  Over the past decade the field has gained tremendous ground, including nanomedicine.

Nanotechnology The concept of nanotechnology is defined as an art handling of tiny particles (1nm= m). The structures have different properties.

Nanomedicines. Nanomedicines for diagnosis and therapy.

Nanoparticle is a general term covering any structure built on a nanometer scale. In medical science, nanoparticles are structures on a nm scale,

3.3 Cell Membrane KEY CONCEPT The cell membrane is a barrier that separates a cell from the external environment.

Nanomedicine - Medicine of the future. Medical application of nanotechnology – Nanotechnology: the study of the control of matter at the atomic/molecular.

CANCER. Cancer: Caused by a mutation in a gene that codes for a checkpoint protein. The cell loses control over cell division and so divides at a rapid.

Drug Carrier Systems Targeted to Widely Dispersed Cells Prof. Dr. Basavaraj K. Nanjwade M. Pharm., Ph. D Department of Pharmaceutics KLE University College.

Cancer Objective What is Cancer? Cancer is uncontrolled cell growth. (Mitosis) When you are young, your cells grow fast so because you are growing.

Progress in Cancer Therapy Following Developments in Biopharma

Promise of CNS drug delivery Immersion Studios, Inc. “Lung Nanorobots I” (2001) Alexander Kabanov Parke-Davis Professor of Pharmaceutical Sciences Director,

 The timing and rate of cell division is crucial to normal growth, development, and maintenance of multicellular organisms.

Regulation of the Cell Cycle. How does a cell know when to divide and when not to divide?

Topics in Bioengineering Maura. Fun Links and Inspiration

Targeted inorganic nanodevices for breast cancer diagnosis and therapy Fiandra Luisa Nanomedicine Laboratory Luigi Sacco University Hospital Milan Italy.

By: Joanne Pugliese. Nanotechnology is the science and study of particles at a molecular or atomic level. Manipulation of molecules at the atomic level.

5.3 Regulation of the Cell Cycle KEY CONCEPT Cell cycle regulation is necessary for healthy growth.

GOLD NANOPARTICLES: A POSSIBLE CURE FOR PANCREATIC CANCER

Regulation of the Cell Cycle

Nanomedicine Research at OU

By Basem Mohammed Aqlan Student No

Targeted therapies in hematological malignancies using therapeutic monoclonal antibodies against Eph family receptors Sara Charmsaz, Andrew M. Scott,

iRGD, a tumor-penetrating peptide for tumor-specific drug delivery

BTY100-Lec 2.3 Nanobiotechnology.

Antibody Drug Conjugates Services Antibody-drug conjugates Antibody-drug conjugates (ADCs) are a very important class of highly potent drugs designed as.

Lecture 7: Selective Targeting of Cancer Cells

Production and clinical development of nanoparticles for gene delivery

Avoiding Immune Detection

Drug Affinity Responsive Target Stability (DARTS).

Nanomedicine James Zinckgraf.

Volume 7, Issue 3, Pages (March 2005)

Drug Delivery: Tumor-Targeted Systems

Types of Tumor Vascularization

T cell mediated immunity

How Medicines Work: Stimulation and Inhibition

Antiangiogenics meet nanotechnology

Targeted therapies in hematological malignancies using therapeutic monoclonal antibodies against Eph family receptors Sara Charmsaz, Andrew M. Scott,

Cell membranes are composed of ___ ____________ ______.

Self-assembly in Nature

Self-assembly in Nature

T Cell Activation and proliferation

A, schematic representation of the “classic” role of uPAR in tumor biology. A, schematic representation of the “classic” role of uPAR in tumor biology.

Normalizing the tumor microenvironment

Antiangiogenics meet nanotechnology

Presentation transcript:

Cancer Historically agents given systemically – Agents that kill rapidly dividing cells Find therapeutic dose  Kills tumor cells w/o killing patient – Lots of side effects Localized/targeted delivery is the holy grail – Nanomedicine!! – Also protection from degradation and increased solubility

Nanoparticles – drug throughout Nanocapsules – drug w/in coating PEGylation – makes stealthy Ligand – binds to cell receptor for targeting

Tumor Vasculature Irregularly shaped, big, and leaky Lack of lymph drainage High vessel density

Passive Targeting  EPR Small drugs enter tumor and leave Particles enter and stay – Long circulation time key

Active Targeting EPR + something that binds tumor cells specifically

Targeting  Interfere with signaling when bind (targeting ligand and drug)  Ab tethered to drug  Ligand + drug  depends upon over-expression of surface molecules by tumor cells

Paige

Daruwalla, Cancer Science, 2010; 101; Paige

Daruwalla, Cancer Science, 2010; 101; MoCR IC 50 =1.2  M MCF-7 IC 50 =0.8  M HT-29 IC 50 =0.85  M DLD-1 IC 50 =0.8  M Paige

Daruwalla, Cancer Science, 2010; 101; Shrinidhi

Daruwalla, Cancer Science, 2010; 101; Shrinidhi

Daruwalla, Cancer Science, 2010; 101; Shrinidhi

Daruwalla, Cancer Science, 2010; 101; Anna

Daruwalla, Cancer Science, 2010; 101; Anna

Daruwalla, Cancer Science, 2010; 101; Anna

Daruwalla, Cancer Science, 2010; 101; Felix

Kevin

Lehtinen, PLOS One, 2012; 7(7); e Kevin

Lehtinen, PLOS One, 2012; 7(7); e Inseong

Lehtinen, PLOS One, 2012; 7(7); e Inseong

Lehtinen, PLOS One, 2012; 7(7); e Maura background non-targeted pre-targeted direct target

Lehtinen, PLOS One, 2012; 7(7); e41410 Maura

Lehtinen, PLOS One, 2012; 7(7); e Michael