Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 1 CheRRIE – The importance of Chemical and Radiological Risk in the Indoor Environment for public health Prof. Dimosthenis A. Sarigiannis, PhD Director of Environmental Engineering Laboratory (EnvE-Lab) Department of Chemical Engineering, Aristotle University of Thessaloniki , Greece

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 2 Indoor risks – What and why XyleneTolueneEthylbenzeneBenzene Formaldehyde Benzo[a]pyrene Lung Cancer Nasopharyngeal Cancer Leukemia Liver (metabolism) Interaction at the level of metabolism (inhibition) Effect addition Liver Cancer Larynx Cancer Acetaldehyde Styrene AcroleinAcetoneBenzaldehyde Neurotoxicity Other PAHs Radon Particulate matter PCBs Phthalates Endocrine disruption Flame retardants Pesticides NO 2 CO Eyes, nose, throat irritation Asthma, rhinitis Non-Hodgkins lymphoma Cardiovascular diseases Respiratory diseases Moulds

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 3 Importance of indoor risks

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 4 Exposure to benzene

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 5 Exposure to formaldehyde

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 6 Exposure to acetaldehyde

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 7 Exposure to radon

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 8 Where they come from?

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 9

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 10 Inventorying radioactivity and chemicals emissivity from building materials both traditional and modern used in typical Greek and Bulgarian constructions Calculation of time evolution of annual equivalent and internal dose due to exposure to radiological and chemicals resulting from exposure to the materials of the above structures. Assessment of the health burden on the population from exposure to ionizing radiation and toxic chemicals emitted from the building / construction materials CheRRIE main objectives – addressing building materials

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 11 Execution of field measurements in Greece and Bulgaria and lab analysis on building materials based on international reference standards and calibration tests. Development of a database of the radiological, physical and chemical characteristics of building materials used in Greece and Bulgaria. Use of INTERA platform for computation of population exposure to radiological and chemical hazards based ont time-activity patterns and field/lab emission data. Setting up of an indoor environment and health advanced IT infrastructure based on grid computing to support effective scientific and stakeholder networking in order to better protect public health. How we met the objectives

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 12 Definition of a set of exposure indicators for combined exposure to radiological and chemical hazards in residential and public buildings in the Greece-Bulgaria trans-boundary regions. Development of a methodology to integrate the existing data towards assessing the effect of co-exposure to these hazards, focusing on susceptible population sub-groups, primarily on children of developing age, pregnant women and the elderly. Development of recommendations‭ ‬on radiological and chemical protection of the population. Main impacts

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 13 Improvement in the quality of the materials used in building construction and/or refurbishing in the trans-boundary regions allowing building constructors, raw material producers and recycling companies to base their purchasing decisions for raw materials on the findings of the project whilst protecting public health. Contribution to the European legislation concerning the use of structural/building materials for residential buildings. Enhancement of public awareness of potential health risks of building materials and enhancement of consumer choice in the building material market. Main expected impacts

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 14 CheRRIE organization of work WP 1 Management & Coordination WP 2 Information and Publicity WP3 Measurements in situ and in the laboratory WP3 Measurements in situ and in the laboratory WP4 Meta-analysis of measurement results WP4 Meta-analysis of measurement results WP5 Analysis of results and implications to the regions population WP5 Analysis of results and implications to the regions population WP 6 Staff training

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 15 SOURCE Radioactivity indoor sources Health outcome Exposure – response functions Methodological concept of the CheRRIE approach

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 16 The INTERA/CheRRIE computational platform is a web based software developed to assist the user in assessing cumulative exposure to radiological and chemical emissions found indoors due to building materials The INTERA/CheRRIE computational platform

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 17 The platform comprises four modules: 1.Emissions-concentrations module, linking emission sources to indoor air concentrations through IAQ modelling taking into account indoor physical chemistry 2.Exposure module including models for dermal, inhalation and oral routes reflecting also differences in the loading mechanism and taking into account time activity patterns and variable inhalation rates based on activity, gender and body weight. 3.Internal dosimetry module, linking the temporal variation of exposure to internal dose dynamics through a generic Physiology Based PharmacoKinetic/Dynamic model which accounts for different gender and age class. 4.Risk assessment module for assessing the cancer risks associated to radiological and chemical exposure. INTERA/CheRRIE platform components

Dep. of Chemical Engineering School of Engineering Aristotle Univ. of Thessaloniki CheRRIE Closing eventNovember 30, 2015 Thessaloniki, GR 18 Thank you for your kind attention A connectivity perspective to environment-health interactions