Developmental & Genetic Diseases By Dr. Ghada Ahmed Lecturer of pathology Benha Faculty of Medicine.

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Presentation transcript:

Developmental & Genetic Diseases By Dr. Ghada Ahmed Lecturer of pathology Benha Faculty of Medicine

 Definition  Teratogenic factors: Ch emicals & drugs I onizing radiation I nfection to mother Ch romosomal/ genetic abnormalities

 Severe  Less severe  Later on life

46, XX 46, XY

Permanent change in DNA sequence of certain gene Abnormal gene New properties

 Point mutation

Genetic diseases Genetic defects (Mendelian Disorders) Chromosomal Disorders Diseases with Multifactorial Inheritence

Genetic defects Autosomal linked DominanatRecessiveSex-linkedX-linked

Genetic diseases Genetic defects (Mendelian Disorders) Chromosomal Disorders Diseases with Multifactorial Inheritence

Chromosomal aberration Structural aberrations Deletion Translocation Inversion Numerical aberrations Increased number Decreased number

 Polygenetic diseases  Multi-factorial diseases

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