LYSOSOMES By: Carmelitta Oakley

Lysosomes Characteristics: Acidic interior Contains hydrolytic enzymes Surrounded by a membrane Lysosomes are analogous to the human stomach; the pH within a lysosome is very acidic & the enzymes within work most effectively in this environment.

Functions: Carrying out digestion recycling of cellular organelles the breakdown of viruses and other cellular invaders Single-celled organisms, such as amoebas, use lysosomes to digest their food since they have no process for extracellular digestion.

Lysosomal storage diseases Undegraded material accumulates within the lysosomes of affected individuals Most of these diseases result from deficiencies in single lysosomal enzymes. Example: Gaucher’s disease

Gaucher disease Most common of lysosomal storage diseases Genetic disorder where there’s accumulation of lipids in cells and organs results from a mutation in the gene that encodes a lysosomal enzyme required for the breakdown of glycolipids.

Some Signs & Symptoms: Enlarged liver and spleen Low number of red blood cells (anemia) easy bruising caused by a decrease in blood platelets lung disease bone abnormalities such as bone pain, fractures, and arthritis. Problems with central nervous system